5-Hydroxymethylcytosine (CAS 1123-95-1)
CAS Number:
1123-95-1
Molecular Weight:
141.13
Molecular Formula:
C5H7N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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5-Hydroxymethylcytosine is an altered version of cytosine, a fundamental component of DNA. Its discovery has brought significant insights into the realm of epigenetics, shedding light on its diverse involvement in numerous biological processes. This relatively recent breakthrough has established 5-hmC as a key player in gene expression, DNA methylation, and various cellular functions. Extensive research in the field of epigenetics has confirmed its pivotal role in regulating gene expression, DNA methylation, and other essential cellular functions.
5-Hydroxymethylcytosine (CAS 1123-95-1) References
- The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. | Kriaucionis, S. and Heintz, N. 2009. Science. 324: 929-30. PMID: 19372393
- Genomic mapping of 5-hydroxymethylcytosine in the human brain. | Jin, SG., et al. 2011. Nucleic Acids Res. 39: 5015-24. PMID: 21378125
- Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. | Ficz, G., et al. 2011. Nature. 473: 398-402. PMID: 21460836
- Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. | Pastor, WA., et al. 2011. Nature. 473: 394-7. PMID: 21552279
- Distribution of 5-hydroxymethylcytosine in different human tissues. | Li, W. and Liu, M. 2011. J Nucleic Acids. 2011: 870726. PMID: 21772996
- Uncovering the role of 5-hydroxymethylcytosine in the epigenome. | Branco, MR., et al. 2011. Nat Rev Genet. 13: 7-13. PMID: 22083101
- Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes. | Nestor, CE., et al. 2012. Genome Res. 22: 467-77. PMID: 22106369
- Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation. | Kudo, Y., et al. 2012. Cancer Sci. 103: 670-6. PMID: 22320381
- Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. | Yu, M., et al. 2012. Cell. 149: 1368-80. PMID: 22608086
- Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. | Lian, CG., et al. 2012. Cell. 150: 1135-46. PMID: 22980977
- 5-hydroxymethylcytosine and its potential roles in development and cancer. | Pfeifer, GP., et al. 2013. Epigenetics Chromatin. 6: 10. PMID: 23634848
- Detection and mapping of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore MspA. | Laszlo, AH., et al. 2013. Proc Natl Acad Sci U S A. 110: 18904-9. PMID: 24167255
- Loss of 5-hydroxymethylcytosine in cancer: cause or consequence? | Ficz, G. and Gribben, JG. 2014. Genomics. 104: 352-7. PMID: 25179374
- 5-Hydroxymethylcytosine is a predominantly stable DNA modification. | Bachman, M., et al. 2014. Nat Chem. 6: 1049-55. PMID: 25411882
- The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. | Penn, NW., et al. 1972. Biochem J. 126: 781-90. PMID: 4538516
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Hydroxymethylcytosine, 100 mg | sc-482809 | 100 mg | $490.00 |