Date published: 2025-10-12

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5-Hydroxymethyl-2-furancarboxylic Acid (CAS 6338-41-6)

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Alternate Names:
Sumikis Acid; 5-(Hydroxymethyl)-2-furoic Acid
CAS Number:
6338-41-6
Purity:
≥98%
Molecular Weight:
142.11
Molecular Formula:
C6H6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Hydroxymethyl-2-furancarboxylic acid (HMF), a naturally occurring compound found in various food products. In vitro investigations have further revealed its potential in synthesizing other compounds, including aromatic compounds like vanillin. Despite its extensive utilization, the precise mechanism of action for 5-Hydroxymethyl-2-furancarboxylic acid remains incompletely understood. It is postulated that the compound acts as an antioxidant by scavenging reactive oxygen species (ROS) and impeding lipid peroxidation.


5-Hydroxymethyl-2-furancarboxylic Acid (CAS 6338-41-6) References

  1. Gold-catalyzed aerobic oxidation of 5-hydroxymethylfurfural in water at ambient temperature.  |  Gorbanev, YY., et al. 2009. ChemSusChem. 2: 672-5. PMID: 19593753
  2. Biomass into chemicals: aerobic oxidation of 5-hydroxymethyl-2-furfural into 2,5-furandicarboxylic acid with gold nanoparticle catalysts.  |  Casanova, O., et al. 2009. ChemSusChem. 2: 1138-44. PMID: 19760702
  3. Selective Aerobic Oxidation of 5-(Hydroxymethyl)furfural to 5-Formyl-2-furancarboxylic Acid in Water.  |  Ventura, M., et al. 2016. ChemSusChem. 9: 1096-100. PMID: 27101568
  4. Biotransformation of 5-hydroxymethylfurfural by Acinetobacter oleivorans S27 for the synthesis of furan derivatives.  |  Godan, TK., et al. 2019. Bioresour Technol. 282: 88-93. PMID: 30852336
  5. Biodegradable Oligoesters of ε-Caprolactone and 5-Hydroxymethyl-2-Furancarboxylic Acid Synthesized by Immobilized Lipases.  |  Todea, A., et al. 2019. Polymers (Basel). 11: PMID: 31455024
  6. A versatile Pseudomonas putida KT2440 with new ability: selective oxidation of 5-hydroxymethylfurfural to 5-hydroxymethyl-2-furancarboxylic acid.  |  Xu, Q., et al. 2020. Bioprocess Biosyst Eng. 43: 67-73. PMID: 31535223
  7. Efficient synthesis of 5-hydroxymethyl-2-furancarboxylic acid by Escherichia coli overexpressing aldehyde dehydrogenases.  |  Zhang, XY., et al. 2020. J Biotechnol. 307: 125-130. PMID: 31726082
  8. Improved biosynthesis of 5-hydroxymethyl-2-furancarboxylic acid and furoic acid from biomass-derived furans with high substrate tolerance of recombinant Escherichia coli HMFOMUT whole-cells.  |  Wang, ZW., et al. 2020. Bioresour Technol. 303: 122930. PMID: 32037191
  9. Valorization of Gelidium amansii for dual production of D-galactonic acid and 5-hydroxymethyl-2-furancarboxylic acid by chemo-biological approach.  |  Liu, P., et al. 2020. Microb Cell Fact. 19: 104. PMID: 32410635
  10. Characterization of a thermotolerant aryl-alcohol oxidase from Moesziomyces antarcticus oxidizing 5-hydroxymethyl-2-furancarboxylic acid.  |  Lappe, A., et al. 2021. Appl Microbiol Biotechnol. 105: 8313-8327. PMID: 34643786
  11. Photocatalytic Oxidation of 5-Hydroxymethylfurfural Over Interfacial-Enhanced Ag/TiO2 Under Visible Light Irradiation.  |  Zhang, W., et al. 2022. ChemSusChem. 15: e202102158. PMID: 34914202
  12. Unprecedented Mechanochemical Synthesis and Heterogenization of a C-Scorpionate Au(III) Catalyst for Microwave-Assisted Biomass Valorization.  |  Matias, IAS., et al. 2022. Nanomaterials (Basel). 12: PMID: 35159707
  13. Recent Progress in Metal-Catalyzed Selective Oxidation of 5-Hydroxymethylfurfural into Furan-Based Value-Added Chemicals.  |  Zhang, S., et al. 2023. Chem Rec. 23: e202300019. PMID: 37017486

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Hydroxymethyl-2-furancarboxylic Acid, 250 mg

sc-210346
250 mg
$250.00