Molecular structure of 5-Hydroxydecanoate sodium salt, CAS Number: 71186-53-3
5-Hydroxydecanoate sodium salt (CAS 71186-53-3)
See product citations (7)
Alternate Names:
5-Hydroxycapric acid sodium salt; 5-Hydroxydecanoic acid sodium salt
Application:
5-Hydroxydecanoate sodium salt is an inhibitor of ATP-sensitive K+ channels
CAS Number:
71186-53-3
Purity:
≥98%
Molecular Weight:
210.25
Molecular Formula:
C10H19O3•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Hydroxydecanoate sodium salt (5-HD) is a substrate for mitochondrial outer membrane ACSL (acyl-CoA synthetase) that inhibits ATP-sensitive K+ channels. In neuronal type K sensitive ATP channel currents, 5-Hydroxydecanoate Na diminished the produced activation of the channels by PKG. On perfused rat hearts, 5-Hydroxydecanoate sodium salt has shown the ability to inhibit the toxicity of 6-hyrdoxydopamine on dopaminergic neurons. 5-Hydroxydecanoate sodium salt has displayed a lack of activity in inhibiting oxygen consuming mitochondria derived from skeletal muscle.
5-Hydroxydecanoate sodium salt (CAS 71186-53-3) References
- K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart. | Hanley, PJ., et al. 2002. J Physiol. 542: 735-41. PMID: 12154175
- 5-Hydroxydecanoate inhibits ATP-sensitive K+ channel currents in guinea-pig single ventricular myocytes. | Notsu, T., et al. 1992. Eur J Pharmacol. 220: 35-41. PMID: 1425978
- 5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for beta-oxidation of fatty acids. | Hanley, PJ., et al. 2005. J Physiol. 562: 307-18. PMID: 15513944
- Effects of 5-hydroxydecanoate and ischemic preconditioning on the ischemic-reperfused heart of fed and fasted rats. | Marina Prendes, MG., et al. 2005. J Physiol Biochem. 61: 447-56. PMID: 16440599
- Blockade of the ATP-sensitive K+ channel by 5-hydroxydecanoate in guinea pig ventricular myocytes. | Notsu, T., et al. 1992. J Pharmacol Exp Ther. 260: 702-8. PMID: 1738118
- 5-Hydroxydecanoate inhibits proliferation of hypoxic human pulmonary artery smooth muscle cells by blocking mitochondrial K(ATP) channels. | Wang, T., et al. 2007. Acta Pharmacol Sin. 28: 1531-40. PMID: 17883937
- The mitochondrial ATP-sensitive potassium channel blocker 5-hydroxydecanoate inhibits toxicity of 6-hydroxydopamine on dopaminergic neurons. | Rodriguez-Pallares, J., et al. 2009. Neurotox Res. 15: 82-95. PMID: 19384591
- 5-Hydroxydecanoate and coenzyme A are inhibitors of native sarcolemmal KATP channels in inside-out patches. | Li, X., et al. 2010. Biochim Biophys Acta. 1800: 385-91. PMID: 19931596
- Stimulation of neuronal KATP channels by cGMP-dependent protein kinase: involvement of ROS and 5-hydroxydecanoate-sensitive factors in signal transduction. | Chai, Y. and Lin, YF. 2010. Am J Physiol Cell Physiol. 298: C875-92. PMID: 20053925
- Inhibition of oxygen consumption in skeletal muscle-derived mitochondria by pinacidil, diazoxide, and glibenclamide, but not by 5-hydroxydecanoate. | Montoya-Pérez, R., et al. 2010. J Bioenerg Biomembr. 42: 21-7. PMID: 20066482
- Sildenafil citrate augments myocardial protection in heart transplantation. | Botha, P., et al. 2010. Transplantation. 89: 169-77. PMID: 20098279
- The Effect of Ginsenoside RB1, Diazoxide, and 5-Hydroxydecanoate on Hypoxia-Reoxygenation Injury of H9C2 Cardiomyocytes. | Zhang, H., et al. 2019. Evid Based Complement Alternat Med. 2019: 6046405. PMID: 31915449
- 5-hydroxydecanoate selectively reduces the initial increase in extracellular K+ in ischemic guinea-pig heart. | Sakamoto, K., et al. 1998. Eur J Pharmacol. 348: 31-5. PMID: 9650828
Inhibitor of:
AQP4, and KIR.Substrate of:
ACSL, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Hydroxydecanoate sodium salt, 100 mg | sc-200992 | 100 mg | $89.00 | |||
5-Hydroxydecanoate sodium salt, 500 mg | sc-200992A | 500 mg | $339.00 |