Molecular structure of 5-Hydroxy Diclofenac, CAS Number: 69002-84-2
5-Hydroxy Diclofenac (CAS 69002-84-2)
See product citations (4)
Alternate Names:
2-[(2,6-Dichlorophenyl)amino]-5-hydroxy-benzeneacetic acid
Application:
5-Hydroxy Diclofenac is a metabolite of diclofenac
CAS Number:
69002-84-2
Molecular Weight:
312.15
Molecular Formula:
C14H11Cl2NO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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5-Hydroxy Diclofenac is a metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound that is believed to function via inhibiton of cyclooxygenase (COX). One study using mouse models showed that 5-Hydroxy Diclofenac forms a quinoneimine conjugate that stimulates proliferation of lymph node cells. Other similar studies have found that Diclofenac and its derivatives can be useful in the deconvolution of cytochrome activities.
5-Hydroxy Diclofenac (CAS 69002-84-2) References
- Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. | Mancy, A., et al. 1999. Biochemistry. 38: 14264-70. PMID: 10572000
- Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac. | Kenny, JR., et al. 2004. J Med Chem. 47: 2816-25. PMID: 15139759
- Investigation of the immunogenicity of diclofenac and diclofenac metabolites. | Naisbitt, DJ., et al. 2007. Toxicol Lett. 168: 45-50. PMID: 17123753
- Biosynthesis of drug metabolites using microbes in hollow fiber cartridge reactors: case study of diclofenac metabolism by Actinoplanes species. | Osorio-Lozada, A., et al. 2008. Drug Metab Dispos. 36: 234-40. PMID: 18006646
- Occurrence of diclofenac and selected metabolites in sewage effluents. | Stülten, D., et al. 2008. Sci Total Environ. 405: 310-6. PMID: 18640705
- Liquid chromatography-tandem mass spectrometric assay for diclofenac and three primary metabolites in mouse plasma. | Sparidans, RW., et al. 2008. J Chromatogr B Analyt Technol Biomed Life Sci. 872: 77-82. PMID: 18674973
- Celecoxib inhibits 5-lipoxygenase. | Maier, TJ., et al. 2008. Biochem Pharmacol. 76: 862-72. PMID: 18692027
- Identification of quinone imine containing glutathione conjugates of diclofenac in rat bile. | Waldon, DJ., et al. 2010. Chem Res Toxicol. 23: 1947-53. PMID: 21053927
- Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain. | Tian, Y., et al. 2022. J Med Chem. 65: 6656-6676. PMID: 35500061
- Microbial oxidative metabolism of diclofenac: production of 4'-hydroxydiclofenac using Epiccocum nigrum IMI354292. | Webster, R., et al. 1998. Appl Microbiol Biotechnol. 49: 371-6. PMID: 9615477
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Hydroxy Diclofenac, 1 mg | sc-207033 | 1 mg | $349.00 | |||
5-Hydroxy Diclofenac, 5 mg | sc-207033A | 5 mg | $411.00 | |||
5-Hydroxy Diclofenac, 25 mg | sc-207033B | 25 mg | $806.00 | |||
5-Hydroxy Diclofenac, 100 mg | sc-207033C | 100 mg | $1603.00 |