Date published: 2025-12-31

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5-Fluoroindole (CAS 399-52-0)

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Alternate Names:
NSC 88613
CAS Number:
399-52-0
Molecular Weight:
135.14
Molecular Formula:
C8H6FN
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Fluoroindole is an aromatic heterocyclic compound formed by the fusion of an indole ring with a fluorine atom. This compound exhibits a broad spectrum of biological activities. It has proven instrumental in scientific research, serving as useful to explore the structure and function of enzymes, receptors, and various proteins. Moreover, 5-Fluoroindole has been used in the study of DNA and RNA.


5-Fluoroindole (CAS 399-52-0) References

  1. Ionization potentials of fluoroindoles and the origin of nonexponential tryptophan fluorescence decay in proteins.  |  Liu, T., et al. 2005. J Am Chem Soc. 127: 4104-13. PMID: 15771548
  2. Utilization of indole analogs by carrot and tobacco cell tryptophan synthase in vivo and in vitro.  |  Widholm, JM. 1981. Plant Physiol. 67: 1101-4. PMID: 16661817
  3. Ground and electronically excited singlet-state structures of 5-fluoroindole deduced from rotationally resolved electronic spectroscopy and ab initio theory.  |  Brand, C., et al. 2012. Chemphyschem. 13: 3134-8. PMID: 22730106
  4. Interaction study between HCV NS5A-D2 and NS5B using 19F NMR.  |  Dujardin, M., et al. 2018. J Biomol NMR. 70: 67-76. PMID: 29218486
  5. Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa.  |  Shanina, E., et al. 2021. Glycobiology. 31: 159-165. PMID: 32573695
  6. CRISPR based targeted genome editing of Chlamydomonas reinhardtii using programmed Cas9-gRNA ribonucleoprotein.  |  Dhokane, D., et al. 2020. Mol Biol Rep. 47: 8747-8755. PMID: 33074412
  7. Antibiofilm and Antivirulence Properties of Indoles Against Serratia marcescens.  |  Sethupathy, S., et al. 2020. Front Microbiol. 11: 584812. PMID: 33193228
  8. Soluble Methane Monooxygenase Component Interactions Monitored by 19F NMR.  |  Jones, JC., et al. 2021. Biochemistry. 60: 1995-2010. PMID: 34100595
  9. Antifungal activities of fluoroindoles against the postharvest pathogen Botrytis cinerea: In vitro and in silico approaches.  |  Raorane, CJ., et al. 2022. Int J Food Microbiol. 362: 109492. PMID: 34861563
  10. Polymer-induced biofilms for enhanced biocatalysis.  |  Adoni, P., et al. 2022. Mater Horiz. 9: 2592-2602. PMID: 35912866
  11. 19F: A small probe for a giant protein.  |  Cosottini, L., et al. 2023. J Inorg Biochem. 244: 112236. PMID: 37146532
  12. New regulatory mutation affecting some of the tryptophan genes in Pseudomonas putida.  |  Maurer, R. and Crawford, IP. 1971. J Bacteriol. 106: 331-8. PMID: 5573729
  13. 5-Fluoroindole resistance identifies tryptophan synthase beta subunit mutants in Arabidopsis thaliana.  |  Barczak, AJ., et al. 1995. Genetics. 140: 303-13. PMID: 7635295

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Fluoroindole, 1 g

sc-254825
1 g
$47.00

5-Fluoroindole, 5 g

sc-254825A
5 g
$84.00