Molecular structure of 5-Fluoroanthranilic Acid, CAS Number: 446-08-2
5-Fluoroanthranilic Acid (CAS 446-08-2)
Alternate Names:
2-Amino-5-fluorobenzoic Acid
Application:
5-Fluoroanthranilic Acid is an antimetabolite for the tryptophan pathway in yeast
CAS Number:
446-08-2
Purity:
≥98%
Molecular Weight:
155.13
Molecular Formula:
C7H6FNO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Fluoroanthranilic Acid is used for the counterselection of TRP1. It is a used genetic marker in the yeast Saccharoyces Cerevisiae. An antimetabolite for the tryptophan pathway in yeast, and is toxic via its antimetabolite conversion to 5-Fluorotryptophan.
5-Fluoroanthranilic Acid (CAS 446-08-2) References
- A counterselection for the tryptophan pathway in yeast: 5-fluoroanthranilic acid resistance. | Toyn, JH., et al. 2000. Yeast. 16: 553-60. PMID: 10790693
- Two homologous genes, DCW1 (YKL046c) and DFG5, are essential for cell growth and encode glycosylphosphatidylinositol (GPI)-anchored membrane proteins required for cell wall biogenesis in Saccharomyces cerevisiae. | Kitagaki, H., et al. 2002. Mol Microbiol. 46: 1011-22. PMID: 12421307
- Isolation and characterization of the TRP1 gene from the yeast Yarrowia lipolytica and multiple gene disruption using a TRP blaster. | Cheon, SA., et al. 2003. Yeast. 20: 677-85. PMID: 12794929
- New tools for phenotypic analysis in Candida albicans: the WAR1 gene confers resistance to sorbate. | Lebel, K., et al. 2006. Yeast. 23: 249-59. PMID: 16544288
- The spectrum of Trp- mutants isolated as 5-fluoroanthranilate-resistant clones in Saccharomyces bayanus, S. mikatae and S. paradoxus. | Jones, EW., et al. 2008. Yeast. 25: 41-6. PMID: 17924454
- Novel quinazolinone derivatives as 5-HT7 receptor ligands. | Na, YH., et al. 2008. Bioorg Med Chem. 16: 2570-8. PMID: 18083580
- New selectable host-marker systems for multiple genetic manipulations based on TRP1, MET2 and ADE2 in the methylotrophic yeast Hansenula polymorpha. | Cheon, SA., et al. 2009. Yeast. 26: 507-21. PMID: 19653331
- A TRP5/5-fluoroanthranilic acid counter-selection system for gene disruption in Candida guilliermondii. | Foureau, E., et al. 2012. Curr Genet. 58: 245-54. PMID: 22618436
- ¹⁹F magnetic resonance probes for live-cell detection of peroxynitrite using an oxidative decarbonylation reaction. | Bruemmer, KJ., et al. 2014. Chem Commun (Camb). 50: 12311-4. PMID: 25180249
- Biosynthetic Plasticity Enables Production of Fluorinated Aurachins. | Sester, A., et al. 2020. Chembiochem. 21: 2268-2273. PMID: 32216075
- De Novo Biosynthesis and Whole-Cell Catalytic Production of 2-Acetamidophenol in Escherichia coli. | Hou, F., et al. 2022. J Agric Food Chem. 70: 238-246. PMID: 34965133
- A genetic transformation system based on trp1 complementation in Candida glycerinogenes | , et al. (2011). World Journal of Microbiology and Biotechnology. volume 27,: pages 1005–1008.
- Silver complexes with fluoroanthranilic acid isomers: Spectroscopic characterization, antimycobacterial activity and cytotoxic studies over a panel of tumor cells | CM Manzano, DH Nakahata, JC Tenorio… - Inorganica Chimica …, 2020 - Elsevier. 1 March 2020,. Inorganica Chimica Acta. Volume 502,: 119293.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Fluoroanthranilic Acid, 5 g | sc-217185 | 5 g | $72.00 | |||
5-Fluoroanthranilic Acid, 25 g | sc-217185A | 25 g | $76.00 | |||
5-Fluoroanthranilic Acid, 100 g | sc-217185B | 100 g | $242.00 | |||
5-Fluoroanthranilic Acid, 250 g | sc-217185C | 250 g | $747.00 | |||
5-Fluoroanthranilic Acid, 1 kg | sc-217185D | 1 kg | $2862.00 |