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5-Fluoro isatin (CAS 443-69-6)

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Alternate Names:
5-Fluoro-1H-indole-2,3-dione; 5-Fluoro-2,3-indoledione; 5-Fluoroindoline-2,3-dione
Application:
5-Fluoro isatin is a reactant for the preparation of many compounds
CAS Number:
443-69-6
Molecular Weight:
165.12
Molecular Formula:
C8H4FNO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Fluoro isatin, a fluorinated derivative of isatin known for its role in organic synthesis, introduces a fluorine atom at the fifth position of the isatin structure, enhancing its chemical reactivity and potential for forming novel compounds. In research, 5-Fluoro isatin is primarily valued as a versatile intermediate in the synthesis of complex heterocyclic molecules, leveraging its unique electronic properties conferred by the fluorine substitution. This modification alters electron distribution and increases the electrophilic character of the compound, facilitating various nucleophilic reactions essential for constructing pharmacologically interesting frameworks. Scientists utilize 5-Fluoro isatin to explore innovative synthetic pathways and to develop new materials and chemicals that could have significant implications in fields such as material science and molecular biology. The study of this compound aids in understanding how changes in molecular structure affect physical and chemical properties, providing insights that are crucial for advancing non-therapeutic applications in chemistry and related disciplines.


5-Fluoro isatin (CAS 443-69-6) References

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  5. Crystal structure, Hirshfeld analysis and mol-ecular docking with the vascular endothelial growth factor receptor-2 of (3Z)-5-fluoro-3-(hy-droxy-imino)-indolin-2-one.  |  Martins, BB., et al. 2017. Acta Crystallogr E Crystallogr Commun. 73: 987-992. PMID: 28775867
  6. Synthesis and spectroscopic and structural characterization of spiro[indoline-3,3'-indolizine]s formed by 1,3-dipolar cycloadditions between isatins, pipecolic acid and an electron-deficient alkene.  |  Romo, PE., et al. 2021. Acta Crystallogr C Struct Chem. 77: 496-504. PMID: 34482292
  7. Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.  |  He, X., et al. 1995. Nature. 374: 617-22. PMID: 7715701
  8. Impact of substituents on the isatin ring on the reaction between isatins with ortho-phenylenediamine  |  Dowlatabadi, R., Khalaj, A., Rahimian, S., Montazeri, M., Amini, M., Shahverdi, A., & Mahjub, E. 2011. Synthetic Communications. 41(11): 1650-1658.
  9. Synthesis, characterization and in vitro antimicrobial activity of some novel 5-substituted Schiff and Mannich base of isatin derivatives.  |  Prakash, C. R., & Raja, S. 2013. Journal of Saudi Chemical Society. 17(3): 337-344.
  10. Isatin 1-morpholinomethyl, 1-hydroxymethyl, 1-methyl, and their halogenated derivatives, redox behaviour  |  Fernandes, I. P., Silva, B. V., Silva, B. N., Pinto, A. C., Oliveira, S. C. B., & Oliveira-Brett, A. M. 2018. Journal of Electroanalytical Chemistry. 812: 143-152.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Fluoro isatin, 5 g

sc-217181
5 g
$110.00