Molecular structure of 5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt, CAS Number: 103226-10-4
5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt (CAS 103226-10-4)
Alternate Names:
FdUMP
Application:
5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt is used to study the activity and function of thymidylate synthase (TS)
CAS Number:
103226-10-4
Purity:
~85%
Molecular Weight:
326.17 (non-salt)
Molecular Formula:
C9H12FN2O8P•xNa
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt is used to study the activity and function of thymidylate synthase (TS). 5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt (5-FdUMP) is a compound extensively employed in diverse scientific research applications. Derived from naturally occurring uridine, which is a nucleoside present in ribonucleic acid (RNA), 5-FdUMP is a synthetic form of uridine that has undergone modification to introduce a fluorine atom at the 5′ position. This alteration enhances its stability and safeguards it against enzymatic degradation, thereby rendering it a valuable reagent for research purposes.
5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt (CAS 103226-10-4) References
- Determination of 5-fluorouracil and 5-fluoro-2'-deoxyuridine-5'-monophosphate in pancreatic cancer cell line and other biological materials using capillary electrophoresis. | Procházková, A., et al. 2001. J Chromatogr A. 916: 215-24. PMID: 11382294
- Effects of antifolates on the binding of 5-fluoro-2'-deoxyuridine monophosphate to thymidylate synthase. | van der Wilt, CL., et al. 2002. Biochem Pharmacol. 64: 669-75. PMID: 12167486
- Comparative physiologic dispositions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia. | Chadwick, M. and Chang, C. 1976. Cancer Treat Rep. 60: 845-55. PMID: 137772
- Synthesis of 5-ethynyl-2'-deoxyuridine-5'-boranomono phosphate as a potential thymidylate synthase inhibitor. | Khan, SI., et al. 2005. Nucleosides Nucleotides Nucleic Acids. 24: 1047-9. PMID: 16248089
- Discovery of 5'-Substituted 5-Fluoro-2'-deoxyuridine Monophosphate Analogs: A Novel Class of Thymidylate Synthase Inhibitors. | Dasari, M., et al. 2023. ACS Pharmacol Transl Sci. 6: 702-709. PMID: 37200809
- Cytotoxicity of 5-fluoro-5'-O-nitro-2'-deoxyuridine, a new fluorinated pyrimidine derivative, in L1210 cultures. | Roberts, D., et al. 1982. Mol Pharmacol. 22: 760-5. PMID: 6218391
- 5-fluorouracil and 5-fluoro-2'-deoxyuridine follow different metabolic pathways in the induction of cell lethality in L1210 leukaemia. | Roobol, C., et al. 1984. Br J Cancer. 49: 739-44. PMID: 6234011
- Increased formation of 5-fluoro-2'-deoxyuridine 5'-monophosphate from 5-fluorouracil in the presence of 2-deoxy-alpha-D-ribose 1-phosphate and 2'-deoxyuridine in Ehrlich ascites tumor cells. | Tamemasa, O. and Tezuka, M. 1980. Nucleic Acids Symp Ser. s169-72. PMID: 7255189
Inhibitor of:
TMSL3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt, 5 mg | sc-214324 | 5 mg | $224.00 | |||
5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt, 25 mg | sc-214324A | 25 mg | $871.00 |