Molecular structure of 5-Fluoro-2′-deoxyuridine, CAS Number: 50-91-9
5-Fluoro-2′-deoxyuridine (CAS 50-91-9)
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Alternate Names:
Floxuridine; 1-(2-Deoxy-β-D-ribofuranosyl)-5-fluorouracil
Application:
5-Fluoro-2′-deoxyuridine is an experimental antiproliferative agent shown to have activity against variety of neoplasms
CAS Number:
50-91-9
Purity:
≥98%
Molecular Weight:
246.19
Molecular Formula:
C9H11FN2O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Fluoro-2′-deoxyuridine is an experimental anticancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas. 5-Fluoro-2#39-deoxyuridine is an inhibitor of TS. 5-Fluoro-2′-deoxyuridine, a fluorinated pyrimidine nucleoside analog, serves as a prodrug that undergoes activation through liver catalysis. In vitro studies primarily involve cell cultures, utilizing 5-Fluoro-2′-deoxyuridine to investigate its impact on cellular processes such as growth, differentiation, and gene expression. Notably, it has been employed to examine the effects of this drug on DNA synthesis, cell cycle progression, and apoptosis in cell cultures, shedding light on its mechanisms of action and potential therapeutic benefits.
5-Fluoro-2′-deoxyuridine (CAS 50-91-9) References
- Synthesis and biological evaluation of butanoate, retinoate, and bis(2,2,2-trichloroethyl)phosphate derivatives of 5-fluoro-2'-deoxyuridine and 2',5-difluoro-2'-deoxyuridine as potential dual action anticancer prodrugs. | Xia, Z., et al. 1999. Arch Pharm (Weinheim). 332: 286-94. PMID: 10489539
- Comparison of 5-fluorouracil and 5-fluoro-2'-deoxyuridine as an effector in radiation-activated prodrugs. | Shibamoto, Y., et al. 2002. J Chemother. 14: 390-6. PMID: 12420858
- 5-Fluoro-2'-deoxyuridine has effects on mitochondria in CEM T-lymphoblast cells. | Curbo, S., et al. 2004. Nucleosides Nucleotides Nucleic Acids. 23: 1495-8. PMID: 15571284
- Cytostatic activity of a 5-fluoro-2'-deoxyuridine-alendronate conjugate against gastric adenocarcinoma and non-malignant intestinal and fibroblast cell lines. | Weinreich, J., et al. 2012. Anticancer Res. 32: 4299-305. PMID: 23060550
- Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans. | Rooney, JP., et al. 2014. Exp Gerontol. 56: 69-76. PMID: 24704715
- An aptamer intrinsically comprising 5-fluoro-2'-deoxyuridine for targeted chemotherapy. | Kruspe, S. and Hahn, U. 2014. Angew Chem Int Ed Engl. 53: 10541-4. PMID: 25145319
- 3'-O- and 5'-O-Propargyl Derivatives of 5-Fluoro-2'-Deoxyuridine: Synthesis, Cytotoxic Evaluation and Conformational Analysis. | Baraniak, D., et al. 2016. Nucleosides Nucleotides Nucleic Acids. 35: 178-94. PMID: 26914155
- MicroRNA-351 Regulates Two-Types of Cell Death, Necrosis and Apoptosis, Induced by 5-fluoro-2'-deoxyuridine. | Sato, A., et al. 2016. PLoS One. 11: e0153130. PMID: 27071035
- Synthesis and anticancer activity of some 5-fluoro-2'-deoxyuridine phosphoramidates. | Lewandowska, M., et al. 2016. Bioorg Med Chem. 24: 2330-41. PMID: 27073055
- Potent activity of 5-fluoro-2'-deoxyuridine and related compounds against thymidine kinase-deficient (TK-) herpes simplex virus: targeted at thymidylate synthase. | De Clercq, E., et al. 1987. Mol Pharmacol. 32: 286-92. PMID: 3039343
- 5-Fluoro-2'-deoxycytidine as a Probe for the Study of B/Z-DNA Transition by 19F NMR Spectroscopy. | Solodinin, A., et al. 2019. ACS Omega. 4: 19716-19722. PMID: 31788603
- Identification and quantitation of 5-fluorouridine in rat urine after administration of 5-fluorouracil or 5-fluoro-2'-deoxyuridine. | Gelijkens, CF., et al. 1980. Drug Metab Dispos. 8: 363-6. PMID: 6107236
- Synthesis of 2'-deoxyuridine and 5-fluoro-2'-deoxyuridine derivatives and evaluation in antibody targeting studies. | Henn, TF., et al. 1993. J Med Chem. 36: 1570-9. PMID: 8496926
- Comparison of 5-fluoro-2'-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer. | van Laar, JA., et al. 1998. Eur J Cancer. 34: 296-306. PMID: 9640213
Inhibitor of:
Enzyme, and TS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Fluoro-2′-deoxyuridine, 50 mg | sc-202425 | 50 mg | $90.00 | |||
5-Fluoro-2′-deoxyuridine, 100 mg | sc-202425A | 100 mg | $166.00 | |||
5-Fluoro-2′-deoxyuridine, 250 mg | sc-202425B | 250 mg | $343.00 | |||
5-Fluoro-2′-deoxyuridine, 500 mg | sc-202425C | 500 mg | $551.00 | |||
5-Fluoro-2′-deoxyuridine, 1 g | sc-202425D | 1 g | $843.00 |