Molecular structure of 5-Fluoro-2′-deoxycytidine, CAS Number: 10356-76-0
5-Fluoro-2′-deoxycytidine (CAS 10356-76-0)
See product citations (1)
Alternate Names:
2′-deoxy-5-fluoro-Cytidine; FCDR
Application:
5-Fluoro-2′-deoxycytidine is a mechanism-based DNMT inhibitor
CAS Number:
10356-76-0
Purity:
≥98%
Molecular Weight:
245.21
Molecular Formula:
C9H12FN3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mechanism-based DNMT inhibitor, shown to form covalent links with the cysteine residue in the DNMT active site.
5-Fluoro-2′-deoxycytidine (CAS 10356-76-0) References
1. Zheng, Y. G., et al., Chemical Regulation of Epigenetic Modifications: Opportunities for New Cancer Therapy. Med. Res. Rev. 28, 645-687, (2008) Warncke S, et al., Phosphorothioation of oligonucleotides strongly influences the inhibition of bacterial (M.HhaI) and human (Dnmt1) DNA methyltransferases. ChemBioChem. 10, 728-734, (2009) 2. Beumer, J.H., et al., Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice. Clin. Cancer Res. 12, 7483-7491, (2006)Inhibitor of:
Dnmt.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Fluoro-2'-deoxycytidine, 5 mg | sc-252267 | 5 mg | $70.00 |