5-Fluoro-2prime-deoxycytidine CAS: 10356-76-0
MF: C9H12FN3O4
MW: 245.21
A mechanism-based DNMT inhibitor.

5-Fluoro-2′-deoxycytidine (CAS 10356-76-0)

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Synonym: 2′-deoxy-5-fluoro-Cytidine; FCDR
Application: A mechanism-based DNMT inhibitor
CAS Number: 10356-76-0
Purity: ≥98%
Molecular Weight: 245.21
Molecular Formula: C9H12FN3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Mechanism-based DNMT inhibitor, shown to form covalent links with the cysteine residue in the DNMT active site.


References

1. Zheng, Y. G., et al., Chemical Regulation of Epigenetic Modifications: Opportunities for New Cancer Therapy. Med. Res. Rev. 28, 645-687, (2008) Warncke S, et al., Phosphorothioation of oligonucleotides strongly influences the inhibition of bacterial (M.HhaI) and human (Dnmt1) DNA methyltransferases. ChemBioChem. 10, 728-734, (2009) 2. Beumer, J.H., et al., Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice. Clin. Cancer Res. 12, 7483-7491, (2006)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO: >20 mg/mL
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
515328
MDL Number :
MFCD00077348
SMILES :
C1[[email protected]@H]([[email protected]](O[[email protected]]1N2C=C(C(=NC2=O)N)F)CO)O

Download SDS (MSDS)

Certificate of Analysis

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