Date published: 2026-4-26

1-800-457-3801

SCBT Portrait Logo
Seach Input

5-Ethynyl-2′-deoxycytidine (CAS 69075-47-4)

0.0(0)
Write a reviewAsk a question

Alternate Names:
2′-deoxy-5-Ethynylcytidine
CAS Number:
69075-47-4
Molecular Weight:
251.24
Molecular Formula:
C11H13N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

5-Ethynyl-2′-deoxycytidine, a synthetic nucleoside analog crafted from 2′-deoxycytidine, integrates seamlessly into the intricate dance of DNA dynamics. This compound garners attention in research circles for its compelling attributes, particularly its role as a DNA methyltransferase inhibitor. By intricately modulating the methyltransferase activity, it plays a pivotal role in the regulation of gene expression, shedding light on epigenetic mechanisms that underpin various biological processes. Additionally, its ability to act as a substrate for DNA polymerase positions it as useful in the study of DNA replication and repair mechanisms. The dual functionality of 5-Ethynyl-2′-deoxycytidine offers a unique lens through which researchers can explore the complexities of genetic information processing, making it a cornerstone in the investigation of DNA-related phenomena.


5-Ethynyl-2′-deoxycytidine (CAS 69075-47-4) References

  1. 5-Ethynyl-2'-deoxycytidine as a new agent for DNA labeling: detection of proliferating cells.  |  Qu, D., et al. 2011. Anal Biochem. 417: 112-21. PMID: 21683679
  2. Intracellular detection of cytosine incorporation in genomic DNA by using 5-ethynyl-2'-deoxycytidine.  |  Guan, L., et al. 2011. Chembiochem. 12: 2184-90. PMID: 21805552
  3. Click fleximers: a modular approach to purine base-expanded ribonucleoside analogues.  |  St Amant, AH., et al. 2012. Org Biomol Chem. 10: 6521-5. PMID: 22752020
  4. 5-Ethynyl-2'-deoxycytidine: a DNA building block with a 'clickable' side chain.  |  Seela, F., et al. 2012. Acta Crystallogr C. 68: o395-8. PMID: 23007541
  5. Cell Proliferation Method: Click Chemistry Based on BrdU Coupling for Multiplex Antibody Staining.  |  Cappella, P., et al. 2015. Curr Protoc Cytom. 72: 7.34.1-7.34.17. PMID: 25827484
  6. Visualizing nucleic acid metabolism using non-natural nucleosides and nucleotide analogs.  |  Choi, JS. and Berdis, AJ. 2016. Biochim Biophys Acta. 1864: 165-76. PMID: 26004088
  7. Dr Jekyll and Mr Hyde: a strange case of 5-ethynyl-2'-deoxyuridine and 5-ethynyl-2'-deoxycytidine.  |  Ligasová, A., et al. 2016. Open Biol. 6: 150172. PMID: 26740587
  8. Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins.  |  Dembowski, JA. and Deluca, NA. 2017. J Vis Exp.. PMID: 28892026
  9. Propargylated Purine Deoxynucleosides: New Tools for Fluorescence Imaging Strategies.  |  Venkatesham, A., et al. 2019. Molecules. 24: PMID: 30696094
  10. Viral and cellular interactions during adenovirus DNA replication.  |  Charman, M., et al. 2019. FEBS Lett. 593: 3531-3550. PMID: 31764999
  11. 5-Ethynyl-2'-deoxycytidine and 5-ethynyl-2'-deoxyuridine are differentially incorporated in cells infected with HSV-1, HCMV, and KSHV viruses.  |  Manska, S., et al. 2020. J Biol Chem. 295: 5871-5890. PMID: 32205447
  12. Cell-to-cell and genome-to-genome variability of adenovirus transcription tuned by the cell cycle.  |  Suomalainen, M., et al. 2020. J Cell Sci. 134: PMID: 32917739
  13. Monitoring genome-wide replication fork directionality by Okazaki fragment sequencing in mammalian cells.  |  Kit Leng Lui, S., et al. 2021. Nat Protoc. 16: 1193-1218. PMID: 33442052
  14. Effect of Microgroove Structure in PDMS-Based Silicone Implants on Biocompatibility.  |  Chen, Y., et al. 2021. Front Bioeng Biotechnol. 9: 793778. PMID: 35127669
  15. Neural Stem Cells as Carriers of Nucleoside-Conjugated Nanogels: A New Approach toward Cell-Mediated Delivery.  |  Morgenroth, A., et al. 2023. ACS Appl Mater Interfaces. 15: 21792-21803. PMID: 37127284

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Ethynyl-2′-deoxycytidine, 10 mg

sc-497176
10 mg
$367.00