Date published: 2025-9-18

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5-Deazariboflavin (CAS 19342-73-5)

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Alternate Names:
1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxopyrimido[4,5-b]quinolin-10(2H)-yl)-D-ribitol; 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione; Pyrimido[4,5-b]quinoline, D-ribitol deriv.; NCI 0112202; NSC 112202
CAS Number:
19342-73-5
Molecular Weight:
375.38
Molecular Formula:
C18H21N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Deazariboflavin, also recognized as 5-formyltetrahydrofolic acid, holds pivotal significance as an intermediate within the biosynthesis of folates and other vital metabolites. Its role as a key intermediate extends to the biosynthesis of purines, thymidylate, and methionine. Acting as a coenzyme in the metabolism of one-carbon units, 5-Deazariboflavin facilitates the transfer of these units across diverse metabolic pathways. Furthermore, it actively contributes to the biosynthesis of essential vitamins and hormones. Ultimately, 5-Deazariboflavin assumes a position as an indispensable intermediate throughout the synthesis of folates and other significant metabolites.


5-Deazariboflavin (CAS 19342-73-5) References

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  2. Improved chemical syntheses of 1- and 5-deazariboflavin.  |  Carlson, EE. and Kiessling, LL. 2004. J Org Chem. 69: 2614-7. PMID: 15049673
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  4. Steady-state and laser flash induced photoreduction of yeast glutathione reductase by 5-deazariboflavin and by a viologen analogue: stabilization of flavin adenine dinucleotide semiquinone species by complexation.  |  Navarro, JA., et al. 1990. Biochemistry. 29: 6102-7. PMID: 2383572
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  8. Antimalarial activity of a riboflavin analog against Plasmodium vinckei in vivo and Plasmodium falciparum in vitro.  |  Cowden, WB., et al. 1987. Am J Trop Med Hyg. 37: 495-500. PMID: 3688306
  9. Cyclic photophosphorylation reactions catalyzed by ferredoxin, methyl viologen and anthraquinone sulfonate. Use of photochemical reactions to optimize redox poising.  |  Robinson, HH. and Yocum, CF. 1980. Biochim Biophys Acta. 590: 97-106. PMID: 7188859
  10. Transient kinetics of intracomplex electron transfer in the human cytochrome b5 reductase-cytochrome b5 system: NAD+ modulates protein-protein binding and electron transfer.  |  Meyer, TE., et al. 1995. Arch Biochem Biophys. 318: 457-64. PMID: 7733677
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Deazariboflavin, 10 mg

sc-499766
10 mg
$360.00

5-Deazariboflavin, 100 mg

sc-499766A
100 mg
$2600.00