Date published: 2026-4-24

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5-Chlorotryptamine hydrochloride (CAS 3764-94-1)

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Alternate Names:
5-Chloro-3-(2-aminoethyl)indole hydrochloride
CAS Number:
3764-94-1
Molecular Weight:
231.13
Molecular Formula:
C10H11ClN2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Chlorotryptamine hydrochloride is a chemical compound that functions as a serotonin receptor agonist in experimental applications. It acts by binding to and activating serotonin receptors, specifically the 5-HT1 and 5-HT2 receptor subtypes. By mimicking the action of serotonin, 5-Chlorotryptamine hydrochloride may influence cellular signaling pathways and neurotransmission. Its mechanism of action involves the activation of specific serotonin receptors, leading to downstream effects on intracellular signaling cascades and neuronal activity.


5-Chlorotryptamine hydrochloride (CAS 3764-94-1) References

  1. Exploitation of the unusual thermodynamic properties of human myeloperoxidase in inhibitor design.  |  Jantschko, W., et al. 2005. Biochem Pharmacol. 69: 1149-57. PMID: 15794935
  2. Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.  |  Liu, F., et al. 2010. Bioorg Med Chem. 18: 4167-77. PMID: 20537544
  3. Synthesis and evaluation of 1-amino-6-halo-β-carbolines as antimalarial and antiprion agents.  |  Thompson, MJ., et al. 2012. ChemMedChem. 7: 578-86. PMID: 22275299
  4. Design, Synthesis, and Biological Activity of Marinacarboline Analogues as STAT3 Pathway Inhibitors for Docetaxel-Resistant Triple-Negative Breast Cancer.  |  Byun, WS., et al. 2023. J Med Chem. 66: 3106-3133. PMID: 36786551
  5. Engineering Saccharomyces cerevisiae for the de novo Production of Halogenated Tryptophan and Tryptamine Derivatives.  |  Milne, N., et al. 2023. ChemistryOpen. 12: e202200266. PMID: 36929157
  6. The action of 5-hydroxthryptamine and related compounds on the activity of Retzius cells of the leech Hirudo medicinalis.  |  Smith, PA. and Walker, RJ. 1974. Br J Pharmacol. 51: 21-7. PMID: 4441793
  7. Synthesis of C‐14‐labeled novel IKK inhibitor: 2‐[14C]‐N‐(6‐chloro‐9H‐pyrido [3, 4‐b] indol‐8‐yl)‐3‐pyridinecarboxamide  |  Li, Y., & Prakash, S. R. 2005. Journal of Labelled Compounds and Radiopharmaceuticals: The Official Journal of the International Isotope Society. 48(5): 323-330.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Chlorotryptamine hydrochloride, 1 g

sc-472294
1 g
$51.00