Date published: 2025-11-9

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5-chloropyrazine-2-carboxamide (CAS 21279-64-1)

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CAS Number:
21279-64-1
Molecular Weight:
157.56
Molecular Formula:
C5H4ClN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Chloropyrazine-2-carboxamide, a compound characterized by the presence of a chlorine atom on a pyrazine ring, plays a pivotal role in various research applications due to its unique chemical properties. This molecule acts as a versatile intermediate in the synthesis of more complex chemical entities, especially in the realm of organic chemistry and materials science. Its mechanism of action often involves participating in chemical reactions that allow for the introduction or modification of functional groups, thereby altering the electronic and steric properties of resultant compounds. This functionality makes it invaluable in the development of novel materials with specific desired characteristics, such as enhanced conductivity, photoreactivity, or thermal stability. In research laboratories, 5-chloropyrazine-2-carboxamide serves not only as a fundamental building block for synthesizing new compounds but also as a tool for probing the mechanisms of chemical reactions and material properties, facilitating a deeper understanding of molecular interactions and the exploration of new frontiers in chemistry and materials science.


5-chloropyrazine-2-carboxamide (CAS 21279-64-1) References

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  2. Substituted N-Phenylpyrazine-2-carboxamides: synthesis and antimycobacterial evaluation.  |  Dolezal, M., et al. 2009. Molecules. 14: 4180-9. PMID: 19924056
  3. Synthesis and antimycobacterial evaluation of N-substituted 5-chloropyrazine-2-carboxamides.  |  Servusová, B., et al. 2013. Bioorg Med Chem Lett. 23: 3589-91. PMID: 23659859
  4. Vibrational spectroscopic investigations and computational study of 5-tert-butyl-N-(4-trifluoromethylphenyl)pyrazine-2-carboxamide.  |  Joseph, T., et al. 2013. Spectrochim Acta A Mol Biomol Spectrosc. 113: 203-14. PMID: 23727674
  5. Synthesis, antimycobacterial activity and in vitro cytotoxicity of 5-chloro-N-phenylpyrazine-2-carboxamides.  |  Zitko, J., et al. 2013. Molecules. 18: 14807-25. PMID: 24317522
  6. Spectroscopic (FT-IR, FT-Raman), first order hyperpolarizability, NBO analysis, HOMO and LUMO analysis of 5-tert-Butyl-6-chloro-N-[(4-(trifluoromethyl)phenyl]pyrazine-2-carboxamide.  |  Bhagyasree, JB., et al. 2015. Spectrochim Acta A Mol Biomol Spectrosc. 137: 193-206. PMID: 25218229
  7. Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.  |  Zhang, YK., et al. 2017. J Med Chem. 60: 5889-5908. PMID: 28635296
  8. 5-Alkylamino-N-phenylpyrazine-2-carboxamides: Design, Preparation, and Antimycobacterial Evaluation.  |  Ambrożkiewicz, W., et al. 2020. Molecules. 25: PMID: 32231166

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-chloropyrazine-2-carboxamide, 1 g

sc-350901
1 g
$428.00

5-chloropyrazine-2-carboxamide, 5 g

sc-350901A
5 g
$1295.00