Date published: 2026-5-10

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5-Chloroindole (CAS 17422-32-1)

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Application:
5-Chloroindole is a compund which has been has been shown to depress serotonin levels
CAS Number:
17422-32-1
Molecular Weight:
151.59
Molecular Formula:
C8H6ClN
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Chloroindole (5-CI) is an extensively studied indole derivative. With its versatility as a building block, 5-Chloroindole has played a vital role in the synthesis of various compounds. Furthermore, 5-Chloroindole has been a subject of interest in scientific research to explore the biological effects of indole derivatives. Although the mechanism of action of 5-Chloroindole is not fully elucidated, it is believed to function as an inhibitor of COX-2.


5-Chloroindole (CAS 17422-32-1) References

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  4. The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drug.  |  Kelsall, IR., et al. 2007. FEBS Lett. 581: 4749-53. PMID: 17870073
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  7. Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model.  |  Sickmann, HM., et al. 2012. Neurochem Int. 60: 267-75. PMID: 22244844
  8. 5-Chloroindole: a potent allosteric modulator of the 5-HT₃ receptor.  |  Newman, AS., et al. 2013. Br J Pharmacol. 169: 1228-38. PMID: 23594147
  9. Inhibitory effect of indole analogs against Paenibacillus larvae, the causal agent of American foulbrood disease.  |  Alvarado, I., et al. 2017. J Insect Sci. 17: PMID: 29117379
  10. Effects of Intracerebroventricular Glycogen Phosphorylase Inhibitor CP-316,819 Infusion on Hypothalamic Glycogen Content and Metabolic Neuron AMPK Activity and Neurotransmitter Expression in Male Rat.  |  Ibrahim, MMH., et al. 2020. J Mol Neurosci. 70: 647-658. PMID: 31925707
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  12. Discovery of novel heterocyclic derivatives as potential glycogen phosphorylase inhibitors with a cardioprotective effect.  |  Yan, Z., et al. 2022. Bioorg Chem. 129: 106120. PMID: 36108587
  13. Synthesis and biological evaluation of 5H-indolo [3,2-b][1,5]benzothiazepine derivatives, designed as conformationally constrained analogues of the human immunodeficiency virus type 1 reverse transcriptase inhibitor L-737,126.  |  Silvestri, R., et al. 1998. Antivir Chem Chemother. 9: 139-48. PMID: 9875385
  14. Studies on the metabolism of 5-hydroxytryptamine (serotonin). VII. Effects of haloindoles on cerebral 5-HT in various species.  |  Sherman, AD. and Gál, EM. 1976. Psychopharmacol Commun. 2: 285-93. PMID: 996281

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Chloroindole, 1 g

sc-254816
1 g
$57.00