Date published: 2025-12-15

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5-Chloro-8-quinolinol (CAS 130-16-5)

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Alternate Names:
5-Chloro-8-hydroxyquinoline
CAS Number:
130-16-5
Purity:
≥98%
Molecular Weight:
179.60
Molecular Formula:
C9H6ClNO
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Chloro-8-quinolinol is a chemical compound notable for its incorporation of a chlorine atom into the 8-quinolinol framework, enhancing its chemical reactivity and interaction capabilities, particularly in the context of metal coordination. This structural modification allows it to act as an effective chelating agent, forming stable complexes with various metals, which is pivotal in fields such as analytical chemistry for metal detection and quantification in environmental samples. In materials science, the photophysical properties of these metal complexes are explored for potential applications in creating advanced materials with specific optical characteristics, useful in sensors and imaging technologies. Additionally, 5-Chloro-8-quinolinol has been investigated in non-medical microbiological research as a potent antimicrobial compound, where its mechanisms of microbial inhibition are studied to develop non-pharmaceutical antimicrobial coatings for surfaces in public and industrial settings. Through such diverse applications, 5-Chloro-8-quinolinol serves as a valuable tool in scientific research, contributing to our understanding of complex chemical systems and the development of innovative technological solutions.


5-Chloro-8-quinolinol (CAS 130-16-5) References

  1. Salting-out extraction technique for pretreatment in the liquid chromatographic determination of copper(II), aluminum(III), iron(III) and manganese(II) in biological samples.  |  Nagaosa, Y. and Sakata, K. 1998. Talanta. 46: 647-54. PMID: 18967188
  2. Supramolecular synthon pattern in solid clioquinol and cloxiquine (APIs of antibacterial, antifungal, antiaging and antituberculosis drugs) studied by ³⁵Cl NQR, ¹H-¹⁷O and ¹H-¹⁴N NQDR and DFT/QTAIM.  |  Latosińska, JN., et al. 2011. J Mol Model. 17: 1781-800. PMID: 21080020
  3. A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist.  |  Morita, A., et al. 2018. Mol Cancer Ther. 17: 432-442. PMID: 28939557
  4. Nylon-6/chitosan core/shell antimicrobial nanofibers for the prevention of mesh-associated surgical site infection.  |  Keirouz, A., et al. 2020. J Nanobiotechnology. 18: 51. PMID: 32188479
  5. Low-dimensional compounds containing bioactive ligands. Part XIV: High selective antiproliferative activity of tris(5-chloro-8-quinolinolato)gallium(III) complex against human cancer cell lines.  |  Litecká, M., et al. 2020. Bioorg Med Chem Lett. 30: 127206. PMID: 32354569
  6. Identification and Synthesis of DDI-6, a Quinolinol Analog Capable of Activating Both Caenorhabditis elegans and Mouse Spermatozoa.  |  Karuo, Y., et al. 2021. Chem Pharm Bull (Tokyo). 69: 557-563. PMID: 34078802
  7. Highly Regio- and Diastereoselective Tethered Aza-Wacker Cyclizations of Alkenyl Phosphoramidates.  |  Shinde, AH., et al. 2021. J Org Chem. 86: 14732-14758. PMID: 34665630
  8. Gallium(III) Complex with Cloxyquin Ligands Induces Ferroptosis in Cancer Cells and Is a Potent Agent against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells.  |  Hreusova, M., et al. 2022. Bioinorg Chem Appl. 2022: 3095749. PMID: 35502218
  9. Functionalization of Silica Nanoparticles by 5-Chloro-8-quinolinol as a New Nanocomposite for the Efficient Removal and Preconcentration of Al3+ Ions from Water Samples.  |  Al-Wasidi, AS., et al. 2023. ACS Omega. 8: 15276-15287. PMID: 37151541
  10. Ring-Opening Reactions of Phosphoramidate Heterocycles.  |  Thomas, AA., et al. 2023. Tetrahedron. 137: PMID: 37885946

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Chloro-8-quinolinol, 100 g

sc-233335
100 g
$39.00