Molecular structure of 5-Bromo-5-nitro-1,3-dioxane, CAS Number: 30007-47-7
5-Bromo-5-nitro-1,3-dioxane (CAS 30007-47-7)
Alternate Names:
Bronidox; m-DIOXANE
Application:
5-Bromo-5-nitro-1,3-dioxane is An antibacterial agent.
CAS Number:
30007-47-7
Molecular Weight:
212.00
Molecular Formula:
C4H6BrNO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Bromo-5-nitro-1,3-dioxane, also known as Bronidox, exhibits antimicrobial properties against a wide range of microorganisms including gram-negative and gram-positive bacteria, yeast, and fungi. 5-Bromo-5-nitro-1,3-dioxane is employed as a stabilizer and preservative in biological molecules and solutions, such as antibodies and antisera. It finds application in rinse-off cosmetics, where it serves as a preserving agent. Bronidox can be used alone or in combination with methylisothiazolone to enhance its effectiveness.
5-Bromo-5-nitro-1,3-dioxane (CAS 30007-47-7) References
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- N-nitrosoalkanolamines in cosmetics. | Eisenbrand, G., et al. 1991. IARC Sci Publ. 238-41. PMID: 1855860
- Formaldehyde-releasers: relationship to formaldehyde contact allergy. Contact allergy to formaldehyde and inventory of formaldehyde-releasers. | de Groot, AC., et al. 2009. Contact Dermatitis. 61: 63-85. PMID: 19706047
- Development of a solid-phase microextraction gas chromatography with microelectron-capture detection method for the determination of 5-bromo-5-nitro-1,3-dioxane in rinse-off cosmetics. | Fernandez-Alvarez, M., et al. 2010. J Chromatogr A. 1217: 6634-9. PMID: 20444463
- Analysis of multi-class preservatives in leave-on and rinse-off cosmetics by matrix solid-phase dispersion. | Sanchez-Prado, L., et al. 2011. Anal Bioanal Chem. 401: 3293-304. PMID: 21947013
- Development of a multi-preservative method based on solid-phase microextraction-gas chromatography-tandem mass spectrometry for cosmetic analysis. | Alvarez-Rivera, G., et al. 2014. J Chromatogr A. 1339: 13-25. PMID: 24661872
- Formaldehyde may be found in cosmetic products even when unlabelled. | Malinauskiene, L., et al. 2015. Open Med (Wars). 10: 323-328. PMID: 28352713
- A Direct Assay for Measuring Free 25-Hydroxyvitamin D. | Heureux, N., et al. 2017. J AOAC Int. 100: 1318-1322. PMID: 28492143
- GDME-based methodology for the determination of free formaldehyde in cosmetics and hygiene products containing formaldehyde releasers. | Brandão, PF., et al. 2018. Anal Bioanal Chem. 410: 6873-6880. PMID: 30062513
- Alkylarylation of styrenes via direct C(sp3)-Br/C(sp2)-H functionalization mediated by photoredox and copper cooperative catalysis. | Yong, X., et al. 2018. Chem Commun (Camb). 54: 12816-12819. PMID: 30357170
- Potential for repurposing the personal care product preservatives bronopol and bronidox as broad-spectrum antibiofilm agents for topical application. | Lee, VE. and O'Neill, AJ. 2019. J Antimicrob Chemother. 74: 907-911. PMID: 30590494
- Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox). | Ghannoum, M., et al. 1986. Folia Microbiol (Praha). 31: 19-31. PMID: 3082729
- Indium controlled regioselective 1,4-alkylarylation of 1,3-dienes with α-carbonyl alkyl bromides and N-heterocycles. | Gu, CC., et al. 2020. Chem Commun (Camb). 56: 1279-1282. PMID: 31904057
- In vitro skin penetration of bronidox, bronopol and formaldehyde from cosmetics. | López-Sánchez, L., et al. 2021. Regul Toxicol Pharmacol. 122: 104888. PMID: 33577887
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Bromo-5-nitro-1,3-dioxane, 5 g | sc-254789 | 5 g | $123.00 | |||
5-Bromo-5-nitro-1,3-dioxane, 10 g | sc-254789A | 10 g | $165.00 | |||
5-Bromo-5-nitro-1,3-dioxane, 100 g | sc-254789B | 100 g | $226.00 |