Molecular structure of 5-BDBD, CAS Number: 768404-03-1
5-BDBD (CAS 768404-03-1)
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Alternate Names:
5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
Application:
5-BDBD is a potent P2X4 receptor antagonist
CAS Number:
768404-03-1
Molecular Weight:
355.19
Molecular Formula:
C17H11BrN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-BDBD is a chemical compound that functions as a selective antagonist at the serotonin 5-HT6 receptor. It acts by binding to the 5-HT6 receptor and inhibiting its activation by serotonin, thereby blocking the receptor′s downstream signaling pathways. Its ability to modulate the activity of the 5-HT6 receptor without affecting other serotonin receptors makes 5-BDBD a compound for investigating the specific functions of the 5-HT6 receptor in experimental models.
5-BDBD (CAS 768404-03-1) References
- Painful purinergic receptors. | Donnelly-Roberts, D., et al. 2008. J Pharmacol Exp Ther. 324: 409-15. PMID: 18042830
- Investigation of the inhibitory effects of the benzodiazepine derivative, 5-BDBD on P2X4 purinergic receptors by two complementary methods. | Balázs, B., et al. 2013. Cell Physiol Biochem. 32: 11-24. PMID: 23867750
- P2X4 receptor regulates alcohol-induced responses in microglia. | Gofman, L., et al. 2014. J Neuroimmune Pharmacol. 9: 668-78. PMID: 25135400
- Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor. | Wang, M., et al. 2017. Bioorg Med Chem. 25: 3835-3844. PMID: 28554730
- P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology. | Stokes, L., et al. 2017. Front Pharmacol. 8: 291. PMID: 28588493
- 5-BDBD ameliorates an OVA-induced allergic asthma by the reduction of Th2 cytokines production. | Hu, B., et al. 2018. Iran J Basic Med Sci. 21: 364-369. PMID: 29796218
- Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model. | Long, T., et al. 2020. J Headache Pain. 21: 4. PMID: 31937253
- Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke. | Srivastava, P., et al. 2020. Exp Neurol. 329: 113308. PMID: 32289314
- Structural Basis of the Negative Allosteric Modulation of 5-BDBD at Human P2X4 Receptors. | Bidula, S., et al. 2022. Mol Pharmacol. 101: 33-44. PMID: 34718224
- The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39. | Xia, GQ., et al. 2022. Eur J Pharmacol. 916: 174729. PMID: 34973190
- Acupuncture relieves the visceral pain of diarrhea-predominant irritable bowel syndrome rats by regulating P2X4 expression. | Tang, HY., et al. 2022. Am J Transl Res. 14: 5563-5573. PMID: 36105029
- Blocking P2X4 purinergic receptor attenuates alcohol-related liver fibrosis by inhibiting hepatic stellate cell activation through PI3K/AKT signaling pathway. | Li, ZX., et al. 2022. Int Immunopharmacol. 113: 109326. PMID: 36252487
- Modulation of P2X4 receptor activity by ivermectin and 5-BDBD has no effect on the development of ARPKD in PCK rats. | Xu, B., et al. 2022. Physiol Rep. 10: e15510. PMID: 36353932
Inhibitor of:
P2X4, and PAMCI.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-BDBD, 5 mg | sc-290784 | 5 mg | $134.00 | |||
| US: Only available in the US | ||||||
5-BDBD, 25 mg | sc-290784A | 25 mg | $508.00 | |||
| US: Only available in the US | ||||||