5-Azido-6-(tert-butyldimethylsilyl)-2,3-O-isopropylidene L-Gulono-1,4-lactone (CAS 118464-49-6)

5-Azido-6-(tert-butyldimethylsilyl)-2,3-O-isopropylidene L-gulono-1,4-lactone is a compound of interest in chemical biology and synthetic organic chemistry. Its functional groups make it a versatile precursor for the synthesis of various bioactive molecules and chemical probes. Researchers have utilized its azido group for bioorthogonal chemistry, enabling selective labeling of biomolecules in complex biological systems. By incorporating this compound into synthetic pathways, scientists have developed strategies for the site-specific modification of proteins, DNA, and carbohydrates, allowing for the study of biomolecular interactions and cellular processes with high precision. Additionally, its tert-butyldimethylsilyl (TBS) protecting group enhances the stability of the lactone moiety during chemical transformations, facilitating its use as a building block in organic synthesis. Moreover, this compound has been employed in the synthesis of analogs of biologically active molecules, such as vitamins and nucleosides, enabling structure-activity relationship studies and the discovery of new lead compounds in drug development. Ongoing research focuses on further expanding the synthetic utility of this compound and exploring its applications in chemical biology, drug discovery, and materials science, highlighting its significance as a valuable tool in interdisciplinary research endeavors.