5-Amino-1H-indazole-3-carboxylic acid (CAS 78155-77-8)
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5-amino-1H-indazole-3-carboxylic acid holds significant value in scientific research due to its versatile applications. Researchers have employed it in the synthesis of various organic compounds, including drugs and dyes. Moreover, it has found utility in peptide and protein synthesis, as well as polymer synthesis. Its application extends to the exploration of enzyme-catalyzed reactions, shedding light on the intricate structure and function of proteins, as well as DNA and RNA. Remarkably, 5-amino-1H-indazole-3-carboxylic acid has emerged as a promising inhibitor of cyclooxygenase-2 (COX-2), an enzyme pivotal in the production of inflammation-associated prostaglandins. By binding to COX-2, it is believed to effectively impede the enzyme′s catalytic ability, halting the formation of prostaglandins and subsequently curbing inflammation.
5-Amino-1H-indazole-3-carboxylic acid (CAS 78155-77-8) References
- Quantum mechanical study and vibrational spectra of indazolium-3-carboxylate and its decarboxylation product, the N-heterocyclic carbene indazol-3-ylidene. | Schmidt, A., et al. 2009. Phys Chem Chem Phys. 11: 341-8. PMID: 19088990
- Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening. | Lee, ECY., et al. 2021. J Med Chem. 64: 6730-6744. PMID: 33955740
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Amino-1H-indazole-3-carboxylic acid, 250 mg | sc-290770 | 250 mg | $122.00 | |||
5-Amino-1H-indazole-3-carboxylic acid, 1 g | sc-290770A | 1 g | $306.00 |