Molecular structure of 5-AIQ hydrochloride, CAS Number: 93117-07-8
5-AIQ hydrochloride (CAS 93117-07-8)
Alternate Names:
5-Aminoisoquinolinone hydrochloride
Application:
5-AIQ hydrochloride is a PARP-1 inhibitor
CAS Number:
93117-07-8
Molecular Weight:
196.63
Molecular Formula:
C9H8N2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-AIQ hydrochloride is a selective PARP-1 inhibitor. Inhibition of PARP-1 prevents apoptosis via the PARP pathway. 5-AIQ hydrochloride is a chemical compound that consists of a pyrazole ring fused to a pyrimidine ring. It is a hydrochloride salt form of 5-AIQ, which stands for 5-aminoisoquinolinone. The hydrochloride salt form enhances the compound′s stability and solubility
5-AIQ hydrochloride (CAS 93117-07-8) References
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- Role of free radicals and poly(ADP-ribose)polymerase-1 in the development of spinal cord injury: new potential therapeutic targets. | Genovese, T. and Cuzzocrea, S. 2008. Curr Med Chem. 15: 477-87. PMID: 18289003
- Influence of 5-aminoisoquinolin-1-one (5-AIQ) on neutrophil chemiluminescence in rats with transient and prolonged focal cerebral ischemia and after reperfusion. | Hendryk, S., et al. 2008. J Physiol Pharmacol. 59: 811-22. PMID: 19212013
- PARP inhibitors: new partners in the therapy of cancer and inflammatory diseases. | Peralta-Leal, A., et al. 2009. Free Radic Biol Med. 47: 13-26. PMID: 19362586
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- Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress. | Módis, K., et al. 2012. Biochem Pharmacol. 83: 633-43. PMID: 22198485
- Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma. | Roller, DG., et al. 2012. Mol Cancer Ther. 11: 2505-15. PMID: 22962324
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- Antidepressant-Like Actions of Inhibitors of Poly(ADP-Ribose) Polymerase in Rodent Models. | Ordway, GA., et al. 2017. Int J Neuropsychopharmacol. 20: 994-1004. PMID: 29016792
- CD8+ T cells are involved in early inflammation before macrophages in a rat adipose tissue engineering chamber model. | Yuan, Y., et al. 2019. J Tissue Eng Regen Med. 13: 1499-1506. PMID: 30811089
- LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy. | Li, P., et al. 2022. EMBO Mol Med. 14: e14511. PMID: 34779136
Inhibitor of:
Apoptosis, and PARP-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-AIQ hydrochloride, 1 mg | sc-214307 | 1 mg | $93.00 | |||
5-AIQ hydrochloride, 5 mg | sc-214307A | 5 mg | $303.00 |