Date published: 2026-2-7

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5,7-dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine (CAS 87119-67-3)

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CAS Number:
87119-67-3
Molecular Weight:
223.3
Molecular Formula:
C14H13N3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5,7-Dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine (5,7-DMPP) is a small molecule that has captured significant attention in various scientific research fields for its potential applications. This compound, characterized by a five-membered heterocyclic structure comprising a pyrazole ring and a pyrimidine ring, has been the subject of extensive investigations. The pyrazole ring consists of two nitrogen atoms and two carbon atoms, while the pyrimidine ring contains four nitrogen atoms and two carbon atoms. The versatility of 5,7-Dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine has been explored extensively, highlighting its potential as a therapeutic agent, an enzyme inhibitor, and a catalyst in chemical synthesis. In scientific research, it has found utility as an enzyme inhibitor, specifically targeting notable enzymes like cytochrome P450. Additionally, it has been utilized to delve into the intricacies of protein structure and function, particularly in the realm of cytochrome P450 enzymes. The precise mechanism of action of 5,7-Dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine is yet to be fully elucidated. However, current understanding suggests that it acts as an enzyme inhibitor, particularly by binding to the active site of enzymes like cytochrome P450. This binding event hinders the normal catalytic activity of the enzyme, resulting in the inhibition of its function.


5,7-dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine (CAS 87119-67-3) References

  1. Pyrazolopyrimidines Based on 5-Aminopyrazoles Unsubstituted at the Position 1  |  N. L. Nam, I. I. Grandberg & V. I. Sorokin. 2002. Chemistry of Heterocyclic Compounds. 38: 1371–1374.
  2. Synthesis of Functionalized 2-(2-Pyrrolyl)pyrazolo[1,5-a]pyrimidines  |  O. V. Petrova, L. N. Sobenina, A. P. Demenev, A. I. Mikhaleva & I. A. Ushakov. 2003. Russian Journal of Organic Chemistry. 39: 1471–1476.
  3. Catalyst- and Base-Controlled Site-Selective sp2 and sp3 Direct Arylation of 5,7-Dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine Using Aryl Bromides  |  Ibtissam Bassoude, Sabine Berteina-Raboin, Stéphane Massip, Jean-Michel Leger, Christian Jarry, El Mokhtar Essassi, Gérald Guillaumet. 2012. European Journal of Organic Chemistry. 2012: 2572-2578.
  4. A one-pot process for the microwave-assisted synthesis of 7-substituted pyrazolo[1,5-a]pyrimidine  |  Ibtissam Bassoude,ab Zahira Tber,a El Mokhtar Essassi,bc Gérald Guillaumeta and Sabine Berteina-Raboin*a . 2016. SC Adv. 6: 3301-3306.
  5. Orthogonal Palladium-Catalyzed Direct C−H Bond Arylation of Heteroaromatics with Aryl Halides  |  Dr. Laure Théveau, Dr. Cédric Schneider, Dr. Corinne Fruit, Prof. Christophe Hoarau. 2016. ChemCatChem,. 8: 3183-3194.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5,7-dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine, 1 g

sc-280515
1 g
$294.00