Date published: 2026-5-2

1-800-457-3801

SCBT Portrait Logo
Seach Input

5,7-Dihydroxytryptamine hydrobromide (CAS 1841081-30-8)

0.0(0)
Write a reviewAsk a question

See product citations (1)

Alternate Names:
5,7-DHT; 3-(2-Aminoethyl)-1H-indole-5,7-diol
CAS Number:
1841081-30-8
Molecular Weight:
273.10
Molecular Formula:
C10H12N2O2•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

5,7-Dihydroxytryptamine hydrobromide is a compound used in neurochemical research to investigate the function of serotonergic systems. It acts as a neurotoxin that selectively targets serotonin transporters, leading to the disruption of serotonin pathways. By understanding the effects of 5,7-Dihydroxytryptamine hydrobromide on these pathways, researchers can gain insights into the complex roles of serotonin in neurotransmission and the mechanisms that underlie neurotoxicity. The compound′s utility extends to the study of neuronal recovery and plasticity after disruption of serotonergic transmission. As a research tool, 5,7-Dihydroxytryptamine hydrobromide is also valuable in the exploration of molecular and cellular responses to altered serotonin levels within neural tissue.


5,7-Dihydroxytryptamine hydrobromide (CAS 1841081-30-8) References

  1. Possible involvement of descending serotonergic systems in antinociception by centrally administered elcatonin in mice.  |  Nakamoto, H., et al. 1999. Biol Pharm Bull. 22: 691-7. PMID: 10443464
  2. Intrastriatal injection of 5,7-dihydroxytryptamine decreased 5-HT levels in the striatum and suppressed locomotor activity in C57BL/6 mice.  |  Chia, LG., et al. 1999. Neurochem Res. 24: 719-22. PMID: 10447454
  3. 5,7-Dihydroxytryptamine--a selective marker of dopaminergic or serotonergic neurons?  |  Franke, H., et al. 2002. Naunyn Schmiedebergs Arch Pharmacol. 366: 315-8. PMID: 12237744
  4. 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6-hydroxydopamine-lesioned rats.  |  Liu, J., et al. 2007. Brain Res. 1149: 216-22. PMID: 17376410
  5. Attenuation of the effects of d-amphetamine on interval timing behavior by central 5-hydroxytryptamine depletion.  |  Body, S., et al. 2009. Psychopharmacology (Berl). 203: 547-59. PMID: 19018519
  6. 5,7-dihydroxytryptamine injections into the prefrontal cortex and nucleus accumbens differently affect prepulse inhibition and baseline startle magnitude in rats.  |  Mohr, D., et al. 2009. Behav Brain Res. 202: 58-63. PMID: 19447281
  7. Sex-related differences in descending norepinephrine and serotonin controls of spinal withdrawal reflex during intramuscular saline induced muscle nociception in rats.  |  Lei, J., et al. 2011. Exp Neurol. 228: 206-14. PMID: 21238453
  8. Does 5, 7-Dihydroxytryptamine injection into nucleus accumbens cause hyperacusis?  |  Farahani, S., et al. 2019. Neurosci Lett. 705: 246-250. PMID: 30970270
  9. Elimination of Serotonergic Neurons by Stereotaxic Injection of 5,7-Dihydroxytryptamine in the Dorsal Raphe Nuclei of Mice.  |  Cao, L., et al. 2020. J Vis Exp.. PMID: 32420992
  10. The guinea pig myoclonic model: behavioral supersensitivity to 5-hydroxytryptophan induced by intracisternal 5,7-dihydroxytryptamine.  |  Pranzatelli, MR. and Snodgrass, SR. 1987. Eur J Pharmacol. 143: 237-42. PMID: 3500866
  11. Effect of 5,7-dihydroxytryptamine on the development of tolerance to ethanol.  |  Lê, AD., et al. 1980. Psychopharmacology (Berl). 67: 143-6. PMID: 6768090
  12. Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats.  |  Kuhn, CM., et al. 1981. Psychopharmacology (Berl). 73: 188-93. PMID: 6785814
  13. Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists.  |  Millan, MJ., et al. 1993. J Pharmacol Exp Ther. 264: 1364-76. PMID: 8450471
  14. 5,7-Dihydroxytryptamine uptake discriminates living serotonergic cells from dopaminergic cells in rat midbrain culture.  |  Rohrbacher, J., et al. 1995. Neurosci Lett. 199: 207-10. PMID: 8577399
  15. Developmental alterations in 5-hydroxytryptamine concentration and turnover after treatment of neonatal rats with 5,7-dihydroxytryptamine.  |  Mercugliano, M., et al. 1996. Neurobiol Learn Mem. 65: 163-76. PMID: 8833105

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5,7-Dihydroxytryptamine hydrobromide, 10 mg

sc-505629
10 mg
$233.00

5,7-Dihydroxytryptamine hydrobromide, 25 mg

sc-505629A
25 mg
$461.00

5,7-Dihydroxytryptamine hydrobromide, 50 mg

sc-505629B
50 mg
$675.00

5,7-Dihydroxytryptamine hydrobromide, 100 mg

sc-505629C
100 mg
$1250.00