Molecular structure of 5,7-Dichloro-8-quinolinol, CAS Number: 773-76-2
5,7-Dichloro-8-quinolinol (CAS 773-76-2)
Alternate Names:
Chloroxine
Application:
5,7-Dichloro-8-quinolinol is a synthetic antibacterial compound
CAS Number:
773-76-2
Purity:
≥98%
Molecular Weight:
214.05
Molecular Formula:
C9H5Cl2NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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5,7-Dichloro-8-quinolinol acts as a mitochondrial inhibitor, disrupting mitochondrial activities by associating with ATP synthase. It has also shown to have genotoxic effects in in vitro studies. It binds onto the magnesium binding site of the ATP synthase enzyme, inhibiting the creation of an intramolecular hydrogen bond, resulting in the blockage of ATP production. This compound is recognized as an impurity of Cioquinol, a substance with antifungal properties.
5,7-Dichloro-8-quinolinol (CAS 773-76-2) References
- A gas chromatographic determination method of 5-chloro-7-iodo-8-quinolinol and its conjugates in biological fluids. | Chen, C., et al. 1976. Chem Pharm Bull (Tokyo). 24: 97-101. PMID: 131650
- A rapid extractive spectrophotometric method for the determination of tin in canned foods with 5,7-dichloro-8-quinolinol. | Gutierrez, AM., et al. 1985. Talanta. 32: 927-9. PMID: 18963921
- Evidence of steric factors in the fungitoxic mechanisms of 8-quinolinol and its 5- and 7-halogenated analogues. | Gershon, H., et al. 1991. J Pharm Sci. 80: 542-4. PMID: 1941544
- Nitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline). | Jiang, H., et al. 2011. Cancer Lett. 312: 11-7. PMID: 21899946
- Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dichloro-8-quinolinolato-lanthanides. | Chen, ZF., et al. 2013. Eur J Med Chem. 59: 194-202. PMID: 23220648
- Design, synthesis and discovery of andrographolide derivatives against Zika virus infection. | Li, F., et al. 2020. Eur J Med Chem. 187: 111925. PMID: 31838328
- Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species. | Barker, S., et al. 2021. PLoS One. 16: e0248119. PMID: 33764972
- Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer. | Silva, VL., et al. 2021. Cell Death Dis. 12: 395. PMID: 33854036
- Critical Evaluation of Two Qualitative Analytical Approaches for Multiclass Determination of Veterinary Drugs in Bovine Muscle Using UHPLC-Q-Orbitrap: The Wind of Change in Brazilian Monitoring. | Paula, RAO., et al. 2023. Molecules. 28: PMID: 37241891
- Spectrophotometric study of complex formation between oxovanadium (IV) and antiamebic drugs. | Abu-Eittah, R. and El-Nasr, MS. 1976. J Pharm Sci. 65: 1364-8. PMID: 966156
- Synthesis, Structure, Spectroscopic Studies and Magnetic Properties of the Tetrakis(5,7-dichloro-8-quinolinolato)gadolinium(III) Complex | Flavia Artizzu, Kevin Bernot, Andrea Caneschi, Eugenio Coronado, Juan M. Clemente-Juan, Luciano Marchiò, Maria Laura Mercuri, Luca Pilia, Angela Serpe, Paola Deplano. 2008. European Journal of Inorganic Chemistry. 2008: 3820-3826.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5,7-Dichloro-8-quinolinol, 100 g | sc-233473 | 100 g | $117.00 |