5,6-Epoxy-13-cis Retinoic Acid (CAS 81444-57-7)

5,6-Epoxy-13-cis Retinoic Acid is a metabolite of 13-cis-Retinoic acid (sc-205568) with an epoxide on the cyclohexene portion of the compound. 5,6-Epoxy-13-cis Retinoic Acid has been identified as a metabolite of hydroperoxide-dependent cooxidation of 13-cis-Retinoic acid by microsomal and purified prostaglandin H synthase. This metabolite was also identified in cultured human keratinocytes applied with 13-cis-Retinoic acid, and pretreatment with antioxidants decreased its formation, indicating that 5,6-Epoxy-13-cis Retinoic Acid formation involves peroxyl radicals interacting with prostaglandin H synthase.Functioning as a potent regulator of gene expression, this compound has undergone extensive investigation for its potential applications. 13-cis RA has been harnessed in laboratory applications to explore the impacts of gene expression on cellular growth and differentiation. In the realm of scientific research, 13-cis RA has been widely employed to scrutinize how gene expression influences cellular development and how genetic mutations contribute to disease progression.