Molecular structure of 5,6-Dimethyl-2-thiouracil, CAS Number: 28456-54-4
5,6-Dimethyl-2-thiouracil (CAS 28456-54-4)
Application:
5,6-Dimethyl-2-thiouracil is a heterocyclic building block
CAS Number:
28456-54-4
Molecular Weight:
156.21
Molecular Formula:
C6H8N2OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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5,6-Dimethyl-2-thiouracil is a white crystalline powder with limited solubility in water and ethanol. This compound is used as an enzyme inhibitor, a n inhibitor to DNA replication, and a reagent in the study of protein structure and functions. It has been used in the study of the structure and actions of enzymes including thymidylate synthase, thymidine kinase, and thymidine phosphorylase. Additionally, 5,6-Dimethyl-2-thiouracil serves a role in researching the structure and function of DNA replication enzymes, such as DNA polymerase, DNA primase, and DNA ligase. 5,6-Dimethyl-2-thiouracil is a heterocyclic building block.
5,6-Dimethyl-2-thiouracil (CAS 28456-54-4) References
- Analysis of thyreostatic drugs in thyroid samples by ultra-performance liquid chromatography tandem mass spectrometry detection. | Abuín, S., et al. 2008. Anal Chim Acta. 617: 184-91. PMID: 18486656
- Analysis of thyreostatic drugs in thyroid samples by liquid chromatography tandem mass spectrometry: comparison of two sample treatment strategies. | Abuín, S., et al. 2008. J Chromatogr A. 1207: 17-23. PMID: 18768184
- N-H···S and N-H···O hydrogen bonds: 'pure' and 'mixed' R2(2)(8) patterns in the crystal structures of eight 2-thiouracil derivatives. | Hützler, WM. and Egert, E. 2014. Acta Crystallogr C Struct Chem. 70: 241-9. PMID: 24508978
- 2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization. | Murugesan, D., et al. 2018. ACS Infect Dis. 4: 954-969. PMID: 29522317
- Determination of Thyreostats in Urine Using Supported Liquid Extraction and Mixed-Mode Cation-Exchange Solid-Phase Extraction: Screening and Confirmatory Methods. | Tölgyesi, Á., et al. 2018. J Chromatogr Sci. 56: 858-866. PMID: 29878072
- Electrochemical Sensor for the Determination of Methylthiouracil in Meat Samples. | Marco, A., et al. 2022. Sensors (Basel). 22: PMID: 36433439
- Synthesis and sedative-hypnotic effects of N3-allyl- and N1-allyl-5,6-substituted 2-thiouracil derivatives in mice. | Dramiński, M., et al. 1998. Chem Pharm Bull (Tokyo). 46: 1370-3. PMID: 9775432
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5,6-Dimethyl-2-thiouracil, 1 g | sc-233463 | 1 g | $82.00 |