5,5i difluoro Bapta(K+ Salt) (CAS 156027-00-8)
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5,5i difluoro Bapta(K+ Salt) is a low affinity, cell-impermeable non-fluorescent Ca2+ indicator (Kd = 640 nM). This fluorinated BAPTA derivative may be used for NMR analysis of Ca2+ in live cells and tissues in addition to optical imaging studies. BAPTA and its derivatives are calcium chelators that are commonly used to form calcium buffers with well-defined calcium concentrations. BAPTA chelators provide an important means to study the roles of calcium in cells. The AM ester forms of the BAPTA chelators allow for control of the cytosolic calcium concentrations when injected into or incubated with cells. Key advantages of these calcium chelators include relative insensitivity toward intracellular pH change and fast release of calcium.
Additional BAPTA chelators available:
BAPTA, Free Acid (sc-201508)
BAPTA tetrapotassium salt (sc-202076)
BAPTA/AM (sc-202488)
BAPTA-APM (sc-206966)
BAPTA-TMFM (sc-212043)
5,5i difluoro Bapta(AM) (sc-217247)
Bapta-FF (AM) (sc-217696)
BAPTA, Tetrasodium Salt (sc-278716)
5,5i difluoro Bapta(K+ Salt) (CAS 156027-00-8) References
- Novel action of BAPTA series chelators on intrinsic K+ currents in rat hippocampal neurones. | Lancaster, B. and Batchelor, AM. 2000. J Physiol. 522 Pt 2: 231-46. PMID: 10639100
- Rhod-2 based measurements of intracellular calcium in the perfused mouse heart: cellular and subcellular localization and response to positive inotropy. | MacGowan, GA., et al. 2001. J Biomed Opt. 6: 23-30. PMID: 11178577
- BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. | Wie, MB., et al. 2001. Prog Neuropsychopharmacol Biol Psychiatry. 25: 1641-59. PMID: 11642660
- Comparison of human recombinant adenosine A2B receptor function assessed by Fluo-3-AM fluorometry and microphysiometry. | Patel, H., et al. 2003. Br J Pharmacol. 138: 671-7. PMID: 12598421
- Synthesis, structure-activity relationship and in vitro evaluation of coelenterazine and coelenteramine derivatives as inhibitors of lipid peroxidation. | Burton, M., et al. 2003. Free Radic Res. 37: 145-58. PMID: 12653203
- Cytosolic calcium in the ischemic rabbit heart: assessment by pH- and temperature-adjusted rhod-2 spectrofluorometry. | Stamm, C., et al. 2003. Cardiovasc Res. 59: 695-704. PMID: 14499871
- An Excel-based model of Ca2+ diffusion and fura 2 measurements in a spherical cell. | McHugh, JM. and Kenyon, JL. 2004. Am J Physiol Cell Physiol. 286: C342-8. PMID: 14512292
- Ratiometric intracellular calcium imaging in the isolated beating rat heart using indo-1 fluorescence. | Eerbeek, O., et al. 2004. J Appl Physiol (1985). 97: 2042-50. PMID: 15208283
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5,5i difluoro Bapta(K+ Salt), 100 mg | sc-217248 | 100 mg | $413.00 |