![5-(5-Ethylthien-2-yl)-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid - chemical structure image](https://media.scbt.com/product/5-5-ethylthien-2-yl-7-trifluoromethyl-pyrazolo1-5-apyrimidine-2-carboxylic-acid-structure_23_30_b_233092.jpg)
![5-(5-Ethylthien-2-yl)-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid - chemical structure image](https://media.scbt.com/product/5-5-ethylthien-2-yl-7-trifluoromethyl-pyrazolo1-5-apyrimidine-2-carboxylic-acid-structure_23_30_t_233092.jpg "Molecular structure of 5-(5-Ethylthien-2-yl)-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid")
Molecular structure of 5-(5-Ethylthien-2-yl)-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
5-(5-Ethylthien-2-yl)-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
Molecular Weight:
341.31
Molecular Formula:
C14H10F3N3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SJ 172550, or MDMX Inhibitor II, is a potent inhibitor of MDMX that effectively disrupts the interaction between MDMX and p53 peptide, with an EC50 value of 4.3 µM. This compound achieves its inhibitory effect by forming a reversible covalent cysteine adduct within the p53-binding domain of MDMX. This interaction locks MDMX into a conformation that hinders its ability to bind with p53. The inhibitory action of SJ 172550 has significant implications. It induces apoptosis, triggers an increase in the expression of p53 target genes, and ultimately leads to p53-dependent cell death in retinoblastoma cells.
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-(5-Ethylthien-2-yl)-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid, 500 mg | sc-317713 | 500 mg | $270.00 |