Molecular structure of 5,5-Diphenyl-2-thiohydantoin, CAS Number: 21083-47-6
5,5-Diphenyl-2-thiohydantoin (CAS 21083-47-6)
Alternate Names:
5,5-diphenyl-2-sulfanylideneimidazolidin-4-one; DPTH
Application:
5,5-Diphenyl-2-thiohydantoin is a reactant for synthesis of imidazole derivatives
CAS Number:
21083-47-6
Molecular Weight:
268.33
Molecular Formula:
C15H12N2OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5,5-Diphenyl-2-thiohydantoin (DPTH) is a heterocyclic organic compound. In scientific research, 5,5-Diphenyl-2-thiohydantoin serves as useful for studying various biological processes. Although the exact mechanism of action for 5,5-Diphenyl-2-thiohydantoin remains incompletely elucidated, it is believed to exert its biological activities by inhibiting key enzymes involved in biological processes. For instance, the compound has demonstrated inhibition of DNA gyrase, an essential enzyme for bacterial DNA replication. Moreover, it has been found to impede the activity of topoisomerase II, an enzyme critical for DNA replication and repair in eukaryotic cells.
5,5-Diphenyl-2-thiohydantoin (CAS 21083-47-6) References
- Effects of 5,5'-diphenyl-2-thiohydantoin on respiration and oxidative phosphorylation of rat liver mitochondria. | Haettinger, JR., et al. 1975. Chem Biol Interact. 10: 255-64. PMID: 123486
- Assessment of diabetogenic drug activity in the rat: 5,5-diphenyl-2-thiohydantoin. | Mackerer, CR., et al. 1977. J Toxicol Environ Health. 2: 1041-51. PMID: 140944
- Anti-proliferation effect of 5,5-diphenyl-2-thiohydantoin (DPTH) in human vascular endothelial cells. | Shih, CR., et al. 2004. Biochem Pharmacol. 67: 67-75. PMID: 14667929
- Structure and anti-proliferation function of 5,5-diphenyl-2-thiohydantoin (DPTH) derivatives in vascular endothelial cells. | Cheng, CK., et al. 2008. Vascul Pharmacol. 48: 138-42. PMID: 18295547
- Anti-angiogenic action of 5,5-diphenyl-2-thiohydantoin-N10 (DPTH-N10). | Liu, Y., et al. 2008. Cancer Lett. 271: 294-305. PMID: 18649995
- A rapid and efficient ultrasound-assisted synthesis of 5,5-diphenylhydantoins and 5,5-diphenyl-2-thiohydantoins. | Arani, NM. and Safari, J. 2011. Ultrason Sonochem. 18: 640-3. PMID: 20920873
- 5,5-Diaryl-2-thiohydantoins and 5,5-diaryl-N3-substituted-2-thiohydantoins as potential hypolipidemic agents. | Tompkins, JE. 1986. J Med Chem. 29: 855-9. PMID: 2939244
- Structural requirements for hydantoins and 2-thiohydantoins to induce lymphoproliferative popliteal lymph node reactions in the mouse. | Kammüller, ME. and Seinen, W. 1988. Int J Immunopharmacol. 10: 997-1010. PMID: 3215711
- Hypotriglyceridemic activity of 5,5'-diphenyl-2-thiohydantoin (DPTH). | Dalton, C. and Verebely, K. 1972. J Pharmacol Exp Ther. 180: 484-91. PMID: 4110840
- Inhibition of the effects of thyroxine by 5,5-diphenyl-2-thiohydantoin. | Marx, JV., et al. 1971. Biochem Pharmacol. 20: 3009-20. PMID: 4332049
- Effect of thyroxine and 5,5-diphenyl-2-thiohydantoin on enzyme activities of rat liver and kidney. | Colton, DG., et al. 1972. Endocrinology. 90: 1521-8. PMID: 4336439
- Reactions of 5,5-diphenyl-2-thiohydantoin with symmetric dibromoalkanes. | Cichoń, Z. and Zejc, A. 1973. Pol J Pharmacol Pharm. 25: 187-93. PMID: 4775875
- Ultrastructural and biochemical alterations of livers from rats treated with 5,5-diphenyl-2-thiohydantoin (DPTH) and thyroxine. | Elfont, EA., et al. 1972. Proc Soc Exp Biol Med. 141: 184-95. PMID: 5082290
- Transformation of normal thyroids into colloid goiters in rats and mice by diphenylthiohydantoin. | Gerber, H., et al. 1994. Endocrinology. 135: 2688-99. PMID: 7988459
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5,5-Diphenyl-2-thiohydantoin, 5 g | sc-227017 | 5 g | $66.00 |