5-(5-Bromo-2-furyl)-4-propyl-4H-1,2,4-triazole-3-thiol
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Manumycin A is an antibiotic originally generated by Streptomyces parvulus that acts as a selective and vigorous inhibitor of Ras farnesyltransferase. The compound has been observed to block the activity of IKKbeta by robustly and rapidly inhibiting TNF alpha induced phosphorylation of IkappaBalpha and NF-kappaB nuclear translocation. Studies indicate that Manumycin A has the ability to induce the dimerization of IKKbeta and dissociation of IKK from IKKgamma/NEMO, the adapter protein. Atherosclerosis studies report that Manumycin A decreases oxidative stress. Additionally, Manumycin A irreversibly inhibits neutral sphingomyelina, and may act to produce nitric oxide and induce apoptosis in leukemia cell studies. Manumycin A is an inhibitor of Farnesyl Transferase and N-SMase.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-(5-Bromo-2-furyl)-4-propyl-4H-1,2,4-triazole-3-thiol, 500 mg | sc-317706 | 500 mg | $180.00 |