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5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one [Intermediates of Pirenzepine] (CAS 28797-48-0)
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5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one [Intermediates of Pirenzepine] is an intermediate of Pirenzepine. Pirenzepine (sc-204197) is a selective antagonist for the M1 muscarinic receptor (mAChR) and is reported to block presynaptic M1 receptors as well as some reported inverse agonist activity. A study investigating the pharmacological characterization of the muscarinic receptors associated with ACh-induced pulmonary vasodilation in a rabbit model of pulmonary hypertension determined the IC50 to be 2.51x10-7M. Additional research studies have investigated the role of Pirenzepine in the pathophysiology of myopia. Other M1 receptor antagonists offered include Telenzepine (sc-204332).
5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one [Intermediates of Pirenzepine] (CAS 28797-48-0) References
- Inverse agonist activity of pirenzepine at M2 muscarinic acetylcholine receptors. | Daeffler, L., et al. 1999. Br J Pharmacol. 126: 1246-52. PMID: 10205015
- M₃muscarinic receptors mediate acetylcholine-induced pulmonary vasodilation in pulmonary hypertension. | Orii, R., et al. 2010. Biosci Trends. 4: 260-6. PMID: 21068480
- Presynaptic muscarinic receptor subtypes involved in the enhancement of spontaneous GABAergic postsynaptic currents in hippocampal neurons. | González, JC., et al. 2011. Eur J Neurosci. 33: 69-81. PMID: 21091801
- The interaction between tropomyosin-related kinase B receptors and presynaptic muscarinic receptors modulates transmitter release in adult rodent motor nerve terminals. | Garcia, N., et al. 2010. J Neurosci. 30: 16514-22. PMID: 21147991
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one [Intermediates of Pirenzepine], 1 g | sc-336962 | 1 g | $50.00 |