Date published: 2026-5-14

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4′-Nitrobenzo-18-crown 6-Ether (CAS 53408-96-1)

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Alternate Names:
2,3-(4-Nitrobenzo)-1,4,7,10,13,16-hexaoxacyclooctadec-2-ene
CAS Number:
53408-96-1
Molecular Weight:
357.36
Molecular Formula:
C16H23NO8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4′-Nitrobenzo-18-crown-6-ether is a chemical compound that incorporates a nitrobenzene moiety linked to an 18-crown-6 ether ring. This compound is of interest in research focusing on host-guest chemistry, where it is often used to study the selective binding and transport of specific cations, particularly potassium ions, due to the crown ether′s ability to encapsulate these ions. The nitro group attached to the benzene ring can influence the binding properties of the crown ether and add a degree of specificity to the interactions being studied. In supramolecular chemistry, 4′-nitrobenzo-18-crown-6-ether is investigated for its potential role in the construction of molecular sensors, as the presence of the nitro group may allow for the development of chemosensors that provide a detectable signal upon cation binding. Additionally, this compound is used in the synthesis of complex organic molecules where the crown ether can serve as a protecting group for potassium ions, facilitating certain types of chemical reactions. Researchers also explore its applications in phase transfer catalysis, leveraging its ability to transfer cations between different phases.


4′-Nitrobenzo-18-crown 6-Ether (CAS 53408-96-1) References

  1. Biomimicking Dual-Responsive Extracellular Matrix Restoring Extracellular Balance through the Na/K-ATPase Pathway.  |  Luan, X., et al. 2019. ACS Appl Mater Interfaces. 11: 21258-21267. PMID: 31117462
  2. Ion-pair induced supramolecular assembly formation for selective extraction and sensing of potassium sulfate.  |  Jagleniec, D., et al. 2019. Chem Sci. 10: 9542-9547. PMID: 32055325
  3. Highly Efficient, Tripodal Ion-Pair Receptors for Switching Selectivity between Acetates and Sulfates Using Solid-Liquid and Liquid-Liquid Extractions.  |  Zaleskaya, M., et al. 2020. Int J Mol Sci. 21: PMID: 33322738
  4. Tripodal, Squaramide-Based Ion Pair Receptor for Effective Extraction of Sulfate Salt.  |  Jagleniec, D., et al. 2021. Molecules. 26: PMID: 34067071
  5. Utilizing an Amino Acid Scaffold to Construct Heteroditopic Receptors Capable of Interacting with Salts under Interfacial Conditions.  |  Jagleniec, D., et al. 2021. Int J Mol Sci. 22: PMID: 34639095
  6. Fluorescence Recognition of Anions Using a Heteroditopic Receptor: Homogenous and Two-Phase Sensing.  |  Zaleskaya-Hernik, M., et al. 2021. Int J Mol Sci. 22: PMID: 34948192
  7. K+-Responsive Crown Ether-Based Amphiphilic Copolymer: Synthesis and Application in the Release of Drugs and Au Nanoparticles.  |  Wang, X., et al. 2022. Polymers (Basel). 14: PMID: 35160395
  8. Construction of K+ responsive surface on SEBS to reduce the hemolysis of preserved erythrocytes.  |  Luan, X., et al. 2019. RSC Adv. 9: 5251-5258. PMID: 35515950

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4′-Nitrobenzo-18-crown 6-Ether, 1 g

sc-290606
1 g
$203.00

4′-Nitrobenzo-18-crown 6-Ether, 5 g

sc-290606A
5 g
$668.00