Molecular structure of 4′-Hydroxychalcone, CAS Number: 2657-25-2
4′-Hydroxychalcone (CAS 2657-25-2)
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Alternate Names:
2-Benzylidene-4′-hydroxyacetophenone; 2-Benzal-4′-hydroxyacetophenone; 4-Cinnamoylphenol
CAS Number:
2657-25-2
Purity:
≥98%
Molecular Weight:
224.25
Molecular Formula:
C15H12O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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4′-Hydroxychalcone, a natural flavonoid belonging to the chalcone class, is present in numerous plants and fruits. As an aromatic ketone, it serves as a precursor to various compounds such as flavonoids, coumarins, and stilbenes. Although the precise mechanism of action for 4′-Hydroxychalcone remains under investigation, it is believed to exert its effects by influencing the activity of various enzymes such as cyclooxygenase-2, lipoxygenase, and cytochrome P450. Additionally, it is thought to modulate the behavior of proteins such as NF-KB and MAPK.
4′-Hydroxychalcone (CAS 2657-25-2) References
- Hydroxychalcones exhibit differential effects on XRE transactivation. | Wang, H., et al. 2005. Toxicology. 207: 303-13. PMID: 15596260
- Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites. | Kohno, Y., et al. 2005. Drug Metab Dispos. 33: 1115-23. PMID: 15863696
- PPARα activation by culinary herbs and spices. | Mueller, M., et al. 2011. Planta Med. 77: 497-504. PMID: 20957597
- The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. | Orlikova, B., et al. 2011. Biochem Pharmacol. 82: 620-31. PMID: 21703248
- Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. | Varinska, L., et al. 2012. Eur J Pharmacol. 691: 125-33. PMID: 22721615
- 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. | Qu, Q., et al. 2014. Biomed Res Int. 2014: 603415. PMID: 25003119
- Cytotoxic effects of 4'-hydroxychalcone on human neuroblastoma cells (SH-SY5Y). | de Moura Escobar, SJ., et al. 2019. Toxicol In Vitro. 61: 104640. PMID: 31493544
- Therapeutic effect of treatment with metformin and/or 4-hydroxychalcone in male Wistar rats with nonalcoholic fatty liver disease. | de Jesús Acosta-Cota, S., et al. 2019. Eur J Pharmacol. 863: 172699. PMID: 31563650
- 4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells. | Alshangiti, AM., et al. 2019. Oxid Med Cell Longev. 2019: 1670759. PMID: 31885773
- Chemopreventive effect of 4'-hydroxychalcone on intestinal tumorigenesis in ApcMin mice. | Chen, Q., et al. 2021. Oncol Lett. 21: 213. PMID: 33510814
- 4-Hydroxyhalcone effects on cisplatin-induced genotoxicity model. | Nazari, A., et al. 2021. Toxicol Res (Camb). 10: 11-17. PMID: 33613968
- Erratum: Chemopreventive effect of 4'-hydroxychalcone on intestinal tumorigenesis in ApcMin mice. | Chen, Q., et al. 2021. Oncol Lett. 21: 480. PMID: 33968196
- Topical Application of 4'-Hydroxychalcone in Combination with tt-Farnesol Is Effective against Candida albicans and Streptococcus mutans Biofilms. | Lobo, CI., et al. 2022. ACS Omega. 7: 22773-22786. PMID: 35811935
- Effect of 4-hydroxychalcone as preventive and curative treatment in Wistar rats with liver injury. | Acosta-Cota, SJ., et al. 2022. Can J Physiol Pharmacol. 100: 1005-1017. PMID: 35985049
- A simplified and easy-to-use HIP HOP assay provides insights into chalcone antifungal mechanisms of action. | Prescott, TAK., et al. 2022. FEBS Lett. 596: 3087-3102. PMID: 36053795
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Angiogenesis.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4′-Hydroxychalcone, 25 g | sc-262260 | 25 g | $137.00 | |||
4′-Hydroxychalcone, 100 g | sc-262260A | 100 g | $530.00 |