Molecular structure of 4′-Hydroxy Warfarin, CAS Number: 24579-14-4
4′-Hydroxy Warfarin (CAS 24579-14-4)
Application:
4′-Hydroxy Warfarin is a metabolite of Warfarin
CAS Number:
24579-14-4
Molecular Weight:
324.33
Molecular Formula:
C19H16O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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4′-Hydroxy Warfarin is a metabolite of Warfarin. Its primary purpose in scientific research is to investigate the mechanism of action of warfarin. By studying 4-Hydroxywarfarin, researchers gain insights into warfarin′s mechanism of action and explore its biochemical properties. The mechanism of action of 4-Hydroxywarfarin closely resembles that of warfarin as both compounds inhibit the activity of vitamin K epoxide reductase—an enzyme in the liver′s synthesis of clotting factors.
4′-Hydroxy Warfarin (CAS 24579-14-4) References
- Re-engineering of CYP2C9 to probe acid-base substrate selectivity. | Tai, G., et al. 2008. Drug Metab Dispos. 36: 1992-7. PMID: 18606741
- Warfarin is an effective modifier of multiple UDP-glucuronosyltransferase enzymes: evaluation of its potential to alter the pharmacokinetics of zidovudine. | Sun, H., et al. 2015. J Pharm Sci. 104: 244-56. PMID: 25393417
- The measurement of warfarin enantiomers in serum using coupled achiral/chiral, high-performance liquid chromatography (HPLC). | Chu, YQ. and Wainer, IW. 1988. Pharm Res. 5: 680-3. PMID: 3244624
- Aspects of anticoagulant action: a review of the pharmacology, metabolism and toxicology of warfarin and congeners. | Sutcliffe, FA., et al. 1987. Rev Drug Metab Drug Interact. 5: 225-72. PMID: 3333881
- Potentiation of fluroxene (2,2,2-trifluoroethyl vinyl ether) toxicity with polychlorinated biphenyls. | Murphy, MJ., et al. 1979. Toxicol Appl Pharmacol. 48: 87-97. PMID: 36687
- Phenprocoumon metabolites in human plasma; characterization by HPLC and GC-MS. | de Vries, JX., et al. 1986. Eur J Clin Pharmacol. 29: 591-4. PMID: 3956564
- Interaction of the anticoagulant drug warfarin and its metabolites with human plasma albumin. | O'Reilly, RA. 1969. J Clin Invest. 48: 193-202. PMID: 5765021
- Composition of cytochrome P-450 isozymes from hepatic microsomes of C57BL/6 and DBA/2 mice assessed by warfarin metabolism, immunoinhibition, and immunoelectrophoresis with anti-(rat cytochrome P-450). | Kaminsky, LS., et al. 1984. Eur J Biochem. 141: 141-8. PMID: 6723656
- Effects of induction on R- and S-warfarin and metabolite concentrations in rat plasma. | Fasco, MJ. and Cashin, MJ. 1980. Toxicol Appl Pharmacol. 56: 101-9. PMID: 7444959
- Biliary and urinary excretion of [14C]warfarin in rabbits. | Wong, LT. and Solomonraj, G. 1980. Xenobiotica. 10: 201-10. PMID: 7467404
- Stereochemical biotransformation of warfarin as a probe of the homogeneity and mechanism of microsomal hydroxylases. | Pohl, LR., et al. 1977. Biochem Pharmacol. 26: 109-14. PMID: 836331
- 14C-warfarin excretion in the rat | Losito, R., & Rousseau, M. A. 1972. Thrombosis and Haemostasis. 27(02): 300-308.
- Workshop: Warfarin drug interactions: Detection, prediction, prevention | Wittkowsky, A. K. 1996. Journal of Thrombosis and Thrombolysis. 2: 295-299.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4′-Hydroxy Warfarin, 5 mg | sc-210195 | 5 mg | $510.00 |