Molecular structure of 4′-Hydroxy Tamoxifen, CAS Number: 82413-23-8
4′-Hydroxy Tamoxifen (CAS 82413-23-8)
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Alternate Names:
Afimoxifene; Tamogel
Application:
4′-Hydroxy Tamoxifen is a metabolite of Tamoxifen
CAS Number:
82413-23-8
Purity:
≥95%
Molecular Weight:
387.51
Molecular Formula:
C26H29NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4′-Hydroxy Tamoxifen is a metabolite of Tamoxifen. 4′-Hydroxy Tamoxifen serves as useful widely employed for studying estrogen receptor modulation in different cells and tissues. Furthermore, it has the potential to influence lipid and carbohydrate metabolism, as well as the expression of specific genes. Moreover, it exerts an impact on hormone production, including estradiol and progesterone, and can lead to changes in various neurotransmitter levels.
4′-Hydroxy Tamoxifen (CAS 82413-23-8) References
- The selective estrogen receptor modulator 4-hydroxy tamoxifen induces G1 arrest and apoptosis of multiple myeloma cell lines. | Gauduchon, J., et al. 2003. Ann N Y Acad Sci. 1010: 321-5. PMID: 15033743
- Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen. | Johnson, MD., et al. 2004. Breast Cancer Res Treat. 85: 151-9. PMID: 15111773
- Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen. | Lim, YC., et al. 2005. Cancer Chemother Pharmacol. 55: 471-8. PMID: 15685451
- Therapeutic potential of new 4-hydroxy-tamoxifen-loaded pH-gradient liposomes in a multiple myeloma experimental model. | Urbinati, G., et al. 2010. Pharm Res. 27: 327-39. PMID: 20033476
- Androgen receptor and heterogeneous nuclear ribonucleoprotein K colocalize in the nucleoplasm and are modulated by bicalutamide and 4-hydroxy-tamoxifen in prostatic cancer cell lines. | Barboro, P., et al. 2011. Prostate. 71: 1466-79. PMID: 21321982
- Reversal of acquired resistance to adriamycin in CHO cells by tamoxifen and 4-hydroxy tamoxifen: role of drug interaction with alpha 1 acid glycoprotein. | Chatterjee, M. and Harris, AL. 1990. Br J Cancer. 62: 712-7. PMID: 2245162
- Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen. | Shahrokh, K., et al. 2012. Biochim Biophys Acta. 1820: 1605-17. PMID: 22677141
- Preparation and delivery of 4-hydroxy-tamoxifen for clonal and polyclonal labeling of cells of the surface ectoderm, skin, and hair follicle. | Chevalier, C., et al. 2014. Methods Mol Biol. 1195: 239-45. PMID: 24504929
- The anticancer drug metabolites endoxifen and 4-hydroxy-tamoxifen induce toxic effects on Daphnia pulex in a two-generation study. | Borgatta, M., et al. 2015. Sci Total Environ. 520: 232-40. PMID: 25817760
- Multigenerational effects of the anticancer drug tamoxifen and its metabolite 4-hydroxy-tamoxifen on Daphnia pulex. | Borgatta, M., et al. 2016. Sci Total Environ. 545-546: 21-9. PMID: 26745289
- Influence of Hydroalcoholic Vehicle on In Vitro Transport of 4-Hydroxy Tamoxifen Through the Mammary Papilla (Nipple). | Alsharif, FM., et al. 2017. AAPS PharmSciTech. 18: 1366-1373. PMID: 27506565
- Immature O-glycans recognized by the macrophage glycoreceptor CLEC10A (MGL) are induced by 4-hydroxy-tamoxifen, oxidative stress and DNA-damage in breast cancer cells. | Kurze, AK., et al. 2019. Cell Commun Signal. 17: 107. PMID: 31455323
- Growth inhibitory effect of 4-hydroxy-tamoxifen on the BT-20 mammary cancer cell line. | Chouvet, C., et al. 1988. J Steroid Biochem. 31: 655-63. PMID: 3199811
- Quantitative measurement of 4-hydroxy tamoxifen in human plasma and mammary tumours by combined gas chromatography/negative chemical ionization mass spectrometry. | Girault, J., et al. 1993. Biol Mass Spectrom. 22: 395-402. PMID: 8357855
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4′-Hydroxy Tamoxifen, 2.5 mg | sc-210192 | 2.5 mg | $390.00 | |||
4′-Hydroxy Tamoxifen, 25 mg | sc-210192A | 25 mg | $2800.00 |