Molecular structure of 4′-Hydroxy Nimesulide, CAS Number: 109032-22-6
4′-Hydroxy Nimesulide (CAS 109032-22-6)
See product citations (4)
Alternate Names:
4-Hydroxy Nimesulide
Application:
4′-Hydroxy Nimesulide is the primary Nimesulide metabolite
CAS Number:
109032-22-6
Purity:
≥99%
Molecular Weight:
324.31
Molecular Formula:
C13H12N2O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4′-Hydroxy Nimesulide is the primary Nimesulide metabolite.
4′-Hydroxy Nimesulide (CAS 109032-22-6) References
- Nimesulide: some pharmaceutical and pharmacological aspects--an update. | Singla, AK., et al. 2000. J Pharm Pharmacol. 52: 467-86. PMID: 10864134
- Mechanisms of NSAID-induced hepatotoxicity: focus on nimesulide. | Boelsterli, UA. 2002. Drug Saf. 25: 633-48. PMID: 12137558
- Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates. | Candelario-Jalil, E. and Sonia León, O. 2003. BMC Pharmacol. 3: 7. PMID: 12807536
- 4-hydroxy nimesulide effects on mitochondria and HepG2 cells. A comparison with nimesulide. | Freitas, CS., et al. 2007. Eur J Pharmacol. 566: 43-9. PMID: 17459371
- Synergic development of pharmacokinetics and bioanalytical methods as support of pharmaceutical research. | Marzo, M., et al. 2016. Int J Immunopathol Pharmacol. 29: 168-79. PMID: 26684641
- LC-MS/MS determination of 4-hydroxynimesulide, an active metabolite of nimesulide and application to bioequivalence study in Indian subjects. | Halder, D., et al. 2019. Eur J Mass Spectrom (Chichester). 25: 399-411. PMID: 30696255
- Antioxidant activity of nimesulide and its main metabolites. | Facino, RM., et al. 1993. Drugs. 46 Suppl 1: 15-21. PMID: 7506157
- Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. | Davis, R. and Brogden, RN. 1994. Drugs. 48: 431-54. PMID: 7527762
- Hepatic side-effects of antibiotics. | Westphal, JF., et al. 1994. J Antimicrob Chemother. 33: 387-401. PMID: 8040106
- The use of cultured hepatocytes to investigate the mechanisms of drug hepatotoxicity. | Castell, JV., et al. 1997. Cell Biol Toxicol. 13: 331-8. PMID: 9298253
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4′-Hydroxy Nimesulide, 1 mg | sc-210191 | 1 mg | $320.00 |