Molecular structure of 4′-Hydroxy Atomoxetine, CAS Number: 435293-66-6
4′-Hydroxy Atomoxetine (CAS 435293-66-6)
Alternate Names:
4′-Hydroxy Atomoxetine also known as 3-Methyl-4-[(1R)-3-(methylamino)-1-phenylpropoxy]phenol
Application:
4′-Hydroxy Atomoxetine is a metabolite of Tomoxetine which is a competitive inhibitor of norepinephrine
CAS Number:
435293-66-6
Purity:
≥97%
Molecular Weight:
271.35
Molecular Formula:
C17H21NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4′-Hydroxy Atomoxetine is a metabolite of Tomoxetine. Tomoxetine (Atomoxetine, LY 139603 sc-204349) is a competitve and specific inhibitor of norepinephrine reuptake while demonstrating weak serotonin and dopamine inhibition as studied in synaptosomes of rat hypothalamus. Additional studies indicate that 4′-Hydroxy Atomoxetine, the (−) optical isomer is more effective than the (+) isomer, LY139602 (ent S-(+)-Atomoxetine Hydrochloride sc-211408). Additionally, in the prefrontal cortex of rats, Tomoxetine was reported to not cause an increase in dopamine within the striatum or nucleus accumbens which may be useful in additional research studies investigating the reward pathways of the brain.
4′-Hydroxy Atomoxetine (CAS 435293-66-6) References
- Update on atomoxetine in the treatment of attention-deficit/hyperactivity disorder. | Vaughan, B., et al. 2009. Expert Opin Pharmacother. 10: 669-76. PMID: 19239401
- Urinary Hesitancy Associated With Atomoxetine. | Gandhi, R., et al. 2017. Prim Care Companion CNS Disord. 19: PMID: 28930379
- Characterisation of seven medications approved for attention-deficit/hyperactivity disorder using in vitro models of hepatic metabolism. | Law, R., et al. 2022. Xenobiotica. 52: 676-686. PMID: 36317558
- Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. | Wong, DT., et al. 1995. Life Sci. 57: 411-41. PMID: 7623609
- Fluoxetine selectively alters 5-hydroxytryptamine1A and gamma-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. | Beck, SG., et al. 1997. J Pharmacol Exp Ther. 281: 115-22. PMID: 9103487
- Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. | Owens, MJ., et al. 1997. J Pharmacol Exp Ther. 283: 1305-22. PMID: 9400006
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4′-Hydroxy Atomoxetine, 1 mg | sc-217050 | 1 mg | $364.00 | |||
4′-Hydroxy Atomoxetine, 2 mg | sc-217050A | 2 mg | $650.00 | |||
4′-Hydroxy Atomoxetine, 5 mg | sc-217050B | 5 mg | $1509.00 | |||
4′-Hydroxy Atomoxetine, 10 mg | sc-217050C | 10 mg | $2507.00 |