Molecular structure of 4′-Aminomethyltrioxsalen hydrochloride, CAS Number: 62442-61-9
4′-Aminomethyltrioxsalen hydrochloride (CAS 62442-61-9)
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Alternate Names:
3-(aminomethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one hydrochloride; 4′-Aminomethyl-4,5′,8-trimethylpsoralen hydrochloride
Application:
4′-Aminomethyltrioxsalen hydrochloride is a psoralen compound DNA intercalator
CAS Number:
62442-61-9
Molecular Weight:
293.75
Molecular Formula:
C15H15NO3•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4′-Aminomethyltrioxsalen hydrochloride is a psoralen compound. Psoralens are a subset of furocoumarins, which have the ability to absorb ultraviolet (UV) light, making them photosensitive agents. Psoralens intercalate with DNA, and upon exposure to UVA light (320–400 nm), they can form covalent bonds with the pyrimidine bases of DNA. If efficiency is high, double substitution and bridging will occur. The "4′-aminomethyl" modification can influence the compound′s binding affinity and specificity to DNA, potentially altering its photobiological activity. The hydrochloride salt form improves the solubility of the compound in water, which is beneficial for biological research applications.
4′-Aminomethyltrioxsalen hydrochloride (CAS 62442-61-9) References
- Human T-cell responses to vaccinia virus envelope proteins. | Tang, J., et al. 2006. J Virol. 80: 10010-20. PMID: 17005679
- Immunogenicity of a psoralen-inactivated dengue virus type 1 vaccine candidate in mice. | Maves, RC., et al. 2010. Clin Vaccine Immunol. 17: 304-6. PMID: 20007362
- Immunogenicity and protective efficacy of a psoralen-inactivated dengue-1 virus vaccine candidate in Aotus nancymaae monkeys. | Maves, RC., et al. 2011. Vaccine. 29: 2691-6. PMID: 21303709
- Metallization of branched DNA origami for nanoelectronic circuit fabrication. | Liu, J., et al. 2011. ACS Nano. 5: 2240-7. PMID: 21323323
- Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A. | Corrionero, A., et al. 2011. Genes Dev. 25: 445-59. PMID: 21363963
- Insect virus: assays for toxic effects and transformation potential in mammalian cells. | Hartig, PC., et al. 1989. Appl Environ Microbiol. 55: 1916-20. PMID: 2675761
- m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. | Zhang, S., et al. 2017. Cancer Cell. 31: 591-606.e6. PMID: 28344040
- PARIS: Psoralen Analysis of RNA Interactions and Structures with High Throughput and Resolution. | Lu, Z., et al. 2018. Methods Mol Biol. 1649: 59-84. PMID: 29130190
- A streamlined protocol for the detection of mRNA-sRNA interactions using AMT-crosslinking in vitro. | Kirsch, R., et al. 2019. Biotechniques. 67: 178-183. PMID: 31462065
- Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA. | Jacq, A., et al. 2021. J Vis Exp.. PMID: 34309599
- Identifying proximal RNA interactions from cDNA-encoded crosslinks with ShapeJumper. | Christy, TW., et al. 2021. PLoS Comput Biol. 17: e1009632. PMID: 34905538
- Synthesis and characterization of new psoralen derivatives with superior photoreactivity with DNA and RNA. | Isaacs, ST., et al. 1977. Biochemistry. 16: 1058-64. PMID: 849407
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4′-Aminomethyltrioxsalen hydrochloride, 5 mg | sc-214292 | 5 mg | $136.00 |