![4′-[[(1-oxopentyl)phenylamino]methyl]-[1,1′-biphenyl]-2-carboxylic acid (CAS 862891-27-8) - chemical structure image](https://media.scbt.com/product/4prime-1-oxopentylphenylaminomethyl-1-1prime-biphenyl-2-carboxylic-acid-862891-27-8-structure_40_54_b_405479.jpg)
![4′-[[(1-oxopentyl)phenylamino]methyl]-[1,1′-biphenyl]-2-carboxylic acid (CAS 862891-27-8) - chemical structure image](https://media.scbt.com/product/4prime-1-oxopentylphenylaminomethyl-1-1prime-biphenyl-2-carboxylic-acid-862891-27-8-structure_40_54_t_405479.jpg "Molecular structure of 4′-[[(1-oxopentyl)phenylamino]methyl]-[1,1′-biphenyl]-2-carboxylic acid, CAS Number: 862891-27-8")
Molecular structure of 4′-[[(1-oxopentyl)phenylamino]methyl]-[1,1′-biphenyl]-2-carboxylic acid, CAS Number: 862891-27-8
4′-[[(1-oxopentyl)phenylamino]methyl]-[1,1′-biphenyl]-2-carboxylic acid (CAS 862891-27-8)
Alternate Names:
CAY10583
Application:
4′-[[(1-oxopentyl)phenylamino]methyl]-[1,1′-biphenyl]-2-carboxylic acid is a BLT2 agonist
CAS Number:
862891-27-8
Molecular Weight:
387.5
Molecular Formula:
C25H25NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Leukotriene B4 (LTB4) promotes a number of leukocyte functions including aggregation, superoxide anion production, stimulation of ion fluxes, chemokinesis and chemotaxis. Two G protein-coupled receptors, BLT1 and BLT2 mediate the actions of LTB4. This chemical is a selective, potent full agonist for BLT2 with an EC50 value of 20 nM (1). It does not displace [3H]-LTB4 binding to BLT1 at concentrations >1 µM and activates BLT2 at significantly lower concentrations than LTB4 (EC50 = 170 nM) (1). This chemical dose dependently increases intracellular calcium stores and induces ERK phosphorylation in Chinese hamster ovary (CHO) cells expressing BLT2 with no effect on CHO cells expressing BLT1 (1).
4′-[[(1-oxopentyl)phenylamino]methyl]-[1,1′-biphenyl]-2-carboxylic acid (CAS 862891-27-8) References
1 Iizuka, Y., Yokomizo, T., Terawaki, K., et al. Characterization of a mouse second leukotriene B4 receptor, mBLT2. BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. J Biol Chem 280(26) 24816-24823 (2005).Activator of:
EP3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4'-[[(1-oxopentyl)phenylamino]methyl]-[1,1'-biphenyl]-2-carboxylic acid, 5 mg | sc-223675 | 5 mg | $60.00 | |||
4'-[[(1-oxopentyl)phenylamino]methyl]-[1,1'-biphenyl]-2-carboxylic acid, 10 mg | sc-223675A | 10 mg | $115.00 |