Molecular structure of 4β-Hydroxy Cholesterol, CAS Number: 17320-10-4
4β-Hydroxy Cholesterol (CAS 17320-10-4)
See product citations (1)
Alternate Names:
5-Cholesten-3β,4β-diol
Application:
4β-Hydroxy Cholesterol is a cholesterol metabolite and endogenous CYP3A marker
CAS Number:
17320-10-4
Molecular Weight:
402.65
Molecular Formula:
C27H46O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
4β-Hydroxy Cholesterol is a metabolite of cholesterol formed by the drug-metabolizing enzyme cytochrome P 450 3A4. It acts as a potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker. 4β-Hydroxy cholesterol is a chemical compound that holds significant value in scientific research, primarily in the realms of cholesterol metabolism, cell proliferation, and apoptosis. Researchers extensively employ it to unravel the intricate relationship between cholesterol and fundamental cellular processes such as cell proliferation and apoptosis. Through its utilization, scientists delve into the biochemical and physiological impacts of cholesterol on cellular mechanisms, thus gaining deeper insights into its regulatory functions and effects on cellular behavior.
4β-Hydroxy Cholesterol (CAS 17320-10-4) References
- Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans. | Marschall, HU., et al. 2005. Gastroenterology. 129: 476-85. PMID: 16083704
- 4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans. | Diczfalusy, U., et al. 2011. Br J Clin Pharmacol. 71: 183-9. PMID: 21219398
- Metabolomics: A Tool Ahead for Understanding Molecular Mechanisms of Drugs and Diseases. | Shah, NJ., et al. 2015. Indian J Clin Biochem. 30: 247-54. PMID: 26089608
- Analysis of native and oxidized low-density lipoprotein oxysterols using gas chromatography-mass spectrometry with selective ion monitoring. | Mori, TA., et al. 1996. Redox Rep. 2: 25-34. PMID: 27414510
- The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe. | Shimabukuro, M., et al. 2016. J Nutr Biochem. 35: 66-73. PMID: 27416363
- First-in-human phase I study of oral S49076, a unique MET/AXL/FGFR inhibitor, in advanced solid tumours. | Rodon, J., et al. 2017. Eur J Cancer. 81: 142-150. PMID: 28624695
- The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib. | Vishwanathan, K., et al. 2018. Br J Clin Pharmacol. 84: 1156-1169. PMID: 29381826
- A First-in-Human Study of the New Oral Selective Estrogen Receptor Degrader AZD9496 for ER+/HER2- Advanced Breast Cancer. | Hamilton, EP., et al. 2018. Clin Cancer Res. 24: 3510-3518. PMID: 29440181
- Assessment of Hepatic Cytochrome P450 3A Activity Using Metabolic Markers in Patients with Renal Impairment. | Kim, AH., et al. 2018. J Korean Med Sci. 33: e298. PMID: 30595680
- Impact of Disease and Treatment Response in Drug-Drug Interaction Studies: Osimertinib and Simvastatin in Advanced Non-Small Cell Lung Cancer. | Vishwanathan, K., et al. 2020. Clin Transl Sci. 13: 41-46. PMID: 31498564
- Pharmacokinetics, pharmacodynamics and safety of the inverse retinoic acid-related orphan receptor γ agonist AZD0284. | Asimus, S., et al. 2020. Br J Clin Pharmacol. 86: 1398-1405. PMID: 32067249
- Physiologically based pharmacokinetic modeling and simulation to predict drug-drug interactions of ivosidenib with CYP3A perpetrators in patients with acute myeloid leukemia. | Prakash, C., et al. 2020. Cancer Chemother Pharmacol. 86: 619-632. PMID: 32978634
- The 1β-Hydroxy-Deoxycholic Acid to Deoxycholic Acid Urinary Metabolic Ratio: Toward a Phenotyping of CYP3A Using an Endogenous Marker? | Magliocco, G., et al. 2021. J Pers Med. 11: PMID: 33672438
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4β-Hydroxy Cholesterol, 10 mg | sc-210208 | 10 mg | $237.00 |