Molecular structure of 4α-Phorbol 12-myristate 13-acetate, CAS Number: 63597-44-4
4α-Phorbol 12-myristate 13-acetate (CAS 63597-44-4)
See product citations (8)
Alternate Names:
4α-PMA
Application:
4α-Phorbol 12-myristate 13-acetate is a phorbol ester analog, binds to TRPV4, increases PGHS-2 mRNA in murine keratinocytes
CAS Number:
63597-44-4
Purity:
≥98%
Molecular Weight:
616.8
Molecular Formula:
C36H56O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4α-Phorbol 12-myristate 13-acetate (4α-PMA) is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA (sc-3576), a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.
4α-Phorbol 12-myristate 13-acetate (CAS 63597-44-4) References
- Activation of a cGMP-stimulated cAMP phosphodiesterase by protein kinase C in a liver Golgi-endosomal fraction. | Geoffroy, V., et al. 1999. Eur J Biochem. 259: 892-900. PMID: 10092879
- The effect of protein kinase C activation on colonic epithelial cellular integrity. | Tepperman, BL., et al. 2000. Eur J Pharmacol. 389: 131-40. PMID: 10688976
- Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. | Watanabe, H., et al. 2002. J Biol Chem. 277: 13569-77. PMID: 11827975
- The second intracellular loop of the glycine transporter 2 contains crucial residues for glycine transport and phorbol ester-induced regulation. | Fornés, A., et al. 2004. J Biol Chem. 279: 22934-43. PMID: 15010455
- Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay. | Saraiva, L., et al. 2004. Eur J Pharmacol. 491: 101-10. PMID: 15140626
- Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. | Vriens, J., et al. 2007. J Biol Chem. 282: 12796-803. PMID: 17341586
- 4 Beta- and 4 alpha-12-O-tetradecanoylphorbol-13-acetate elicit arachidonate release from epidermal cells through different mechanisms. | Fischer, SM., et al. 1991. Cancer Res. 51: 850-6. PMID: 1899047
- Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study. | Klausen, TK., et al. 2009. J Med Chem. 52: 2933-9. PMID: 19361196
- Differential role of PKC isoforms in GnRH and phorbol 12-myristate 13-acetate activation of extracellular signal-regulated kinase and Jun N-terminal kinase. | Dobkin-Bekman, M., et al. 2010. Endocrinology. 151: 4894-907. PMID: 20810567
- Phorbol ester enhancement of neurotransmitter release from rat brain synaptosomes. | Nichols, RA., et al. 1987. J Neurochem. 48: 615-21. PMID: 3098922
- Multifactor regulation of prostaglandin H synthase-2 in murine keratinocytes. | Maldve, RE. and Fischer, SM. 1996. Mol Carcinog. 17: 207-16. PMID: 8989914
- HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways. | Kiehn, J., et al. 1998. J Biol Chem. 273: 25285-91. PMID: 9737994
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4α-Phorbol 12-myristate 13-acetate, 1 mg | sc-202021 | 1 mg | $82.00 | |||
4α-Phorbol 12-myristate 13-acetate, 5 mg | sc-202021A | 5 mg | $459.00 |