Date published: 2025-12-15

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4α-Phorbol 12,13-dibutyrate (CAS 93781-54-5)

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Application:
4α-Phorbol 12,13-dibutyrate is a negative control for sc-202285
CAS Number:
93781-54-5
Purity:
>99%
Molecular Weight:
504.6
Molecular Formula:
C28H40O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4α-Phorbol 12,13-dibutyrate is negative control for phorbol 12,13-dibutyrate (sc-202285). 4α-Phorbol 12,13-dibutyrate is an activator of PKC.


4α-Phorbol 12,13-dibutyrate (CAS 93781-54-5) References

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  2. Phosphoinositide 3-kinase gamma mediates angiotensin II-induced stimulation of L-type calcium channels in vascular myocytes.  |  Quignard, JF., et al. 2001. J Biol Chem. 276: 32545-51. PMID: 11443116
  3. Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay.  |  Saraiva, L., et al. 2004. Eur J Pharmacol. 491: 101-10. PMID: 15140626
  4. Protein kinase C-dependent enhancement of activity of rat brain NCKX2 heterologously expressed in HEK293 cells.  |  Lee, JY., et al. 2006. J Biol Chem. 281: 39205-16. PMID: 17038313
  5. Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4.  |  Vriens, J., et al. 2007. J Biol Chem. 282: 12796-803. PMID: 17341586
  6. Cannabinoid CB1 receptor elevation of intracellular calcium in neuroblastoma SH-SY5Y cells: interactions with muscarinic and delta-opioid receptors.  |  Marini, P., et al. 2009. Biochim Biophys Acta. 1793: 1289-303. PMID: 19445974
  7. New tigliane-type diterpenoids from Euphorbia aellenii Rech. f. with immunomodulatory activity.  |  Ghanadian, M., et al. 2011. Res Pharm Sci. 6: 35-41. PMID: 22049276
  8. Phorbol 12,13-dibutyrate-induced, protein kinase C-mediated contraction of rabbit bladder smooth muscle.  |  Wang, T., et al. 2012. Front Pharmacol. 2: 83. PMID: 22232602
  9. ADP-ribosylation factor translocation correlates with potentiation of GTP gamma S-stimulated phospholipase D activity in membrane fractions of HL-60 cells.  |  Houle, MG., et al. 1995. J Biol Chem. 270: 22795-800. PMID: 7559408
  10. E-cadherin mediates adherens junction organization through protein kinase C.  |  Lewis, JE., et al. 1994. J Cell Sci. 107 (Pt 12): 3615-21. PMID: 7706410
  11. Protein kinase C involvement in maintenance and modulation of noradrenaline release in the mouse brain cortex.  |  Schroeder, GE., et al. 1995. Br J Pharmacol. 116: 2757-63. PMID: 8591001
  12. The structural requirements for phorbol esters to enhance noradrenaline and dopamine release from rat brain cortex.  |  Kotsonis, P. and Majewski, H. 1996. Br J Pharmacol. 119: 115-25. PMID: 8872364
  13. PMA alters folate receptor distribution in the plasma membrane and increases the rate of 5-methyltetrahydrofolate delivery in mature MA104 cells.  |  Lewis, CM., et al. 1998. Biochim Biophys Acta. 1401: 157-69. PMID: 9531971
  14. Substrate phosphorylation in the protein kinase Cgamma knockout mouse.  |  Ramakers, GM., et al. 1999. J Biol Chem. 274: 1873-4. PMID: 9890937

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4α-Phorbol 12,13-dibutyrate, 1 mg

sc-352029
1 mg
$218.00