Molecular structure of 4α-Hydroxy Cholesterol, CAS Number: 34310-86-6
4α-Hydroxy Cholesterol (CAS 34310-86-6)
Alternate Names:
(3β,4α)-Cholest-5-ene-3,4-diol; Cholest-5-ene-3β,4α-diol
Application:
4α-Hydroxy Cholesterol is a potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker
CAS Number:
34310-86-6
Molecular Weight:
402.65
Molecular Formula:
C27H46O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4α-Hydroxy Cholesterol (4HC) is a metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. It is a potential ligand for the nuclear receptor LXR and a new endogenous CYP3A marker. 4α-Hydroxy Cholesterol is involved in regulation of cholesterol homeostasis, cell membrane fluidity, and cell signaling pathways. It has also been shown to have anti-inflammatory, anti-atherosclerotic, and anti-cancer effects.
4α-Hydroxy Cholesterol (CAS 34310-86-6) References
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- A validated liquid chromatography-tandem mass spectrometry method for the quantitative determination of 4β-hydroxycholesterol in human plasma. | van de Merbel, NC., et al. 2011. J Pharm Biomed Anal. 55: 1089-95. PMID: 21507593
- Quantification of 4-beta-hydroxycholesterol in human plasma using automated sample preparation and LC-ESI-MS/MS analysis. | Goodenough, AK., et al. 2011. Chem Res Toxicol. 24: 1575-85. PMID: 21728364
- Biological activities of the LXRα and β agonist, 4β-hydroxycholesterol, and of its isomer, 4α-hydroxycholesterol, on oligodendrocytes: effects on cell growth and viability, oxidative and inflammatory status. | Nury, T., et al. 2013. Biochimie. 95: 518-30. PMID: 23220593
- Improved synthesis and in vitro evaluation of the cytotoxic profile of oxysterols oxidized at C4 (4α- and 4β-hydroxycholesterol) and C7 (7-ketocholesterol, 7α- and 7β-hydroxycholesterol) on cells of the central nervous system. | Nury, T., et al. 2013. Eur J Med Chem. 70: 558-67. PMID: 24211631
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- Quantitation of P450 3A4 endogenous biomarker - 4β-hydroxycholesterol - in human plasma using LC/ESI-MS/MS. | Huang, MQ., et al. 2014. Biomed Chromatogr. 28: 794-801. PMID: 24861746
- Evaluation of 4β-Hydroxycholesterol as a Clinical Biomarker of CYP3A4 Drug Interactions Using a Bayesian Mechanism-Based Pharmacometric Model. | Leil, TA., et al. 2014. CPT Pharmacometrics Syst Pharmacol. 3: e120. PMID: 24964282
- Cholesterol transformations during heat treatment. | Derewiaka, D. and Molińska née Sosińska, E. 2015. Food Chem. 171: 233-40. PMID: 25308664
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- Mass spectrometry profiling of oxysterols in human sperm identifies 25-hydroxycholesterol as a marker of sperm function. | Zerbinati, C., et al. 2017. Redox Biol. 11: 111-117. PMID: 27912195
- Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice. | Nitta, SI., et al. 2018. AAPS J. 20: 61. PMID: 29858698
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- Sensitive UHPLC-MS/MS quantification method for 4β- and 4α-hydroxycholesterol in plasma for accurate CYP3A phenotyping. | Suzuki, Y., et al. 2022. J Lipid Res. 63: 100184. PMID: 35181316
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4α-Hydroxy Cholesterol, 1 mg | sc-363858 | 1 mg | $520.00 | |||
4α-Hydroxy Cholesterol, 2 mg | sc-363858A | 2 mg | $921.00 | |||
4α-Hydroxy Cholesterol, 5 mg | sc-363858B | 5 mg | $1727.00 |