Date published: 2025-10-2

1-800-457-3801

SCBT Portrait Logo
Seach Input

4-(Trifluoromethyl)aniline (CAS 455-14-1)

0.0(0)
Write a reviewAsk a question

See product citations (1)

Alternate Names:
P-Trifluoromethylaniline
Application:
4-(Trifluoromethyl)aniline is 4-Substituted aniline derivative which exerts special hematotoxicity on the red blood cells and also induces leukocytosis
CAS Number:
455-14-1
Purity:
≥95%
Molecular Weight:
161.12
Molecular Formula:
C7H6F3N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

4-(Trifluoromethyl)aniline, also known as 4-TFA, is a versatile organic compound with wide-ranging applications in scientific research and industrial settings. This colorless liquid possesses a strong aromatic odor and is derived from aniline, a compound found naturally in various substances. The precise mechanism of action of 4-(Trifluoromethyl)aniline remains incompletely understood. However, it is believed to act as a catalyst in synthesizing other compounds. Furthermore, 4-(Trifluoromethyl)aniline is thought to function as a nucleophile, participating in covalent bond formation, and as an electron-donating group, contributing to the creation of coordination complexes.


4-(Trifluoromethyl)aniline (CAS 455-14-1) References

  1. Synthetic Studies on Tricyclic Diterpenoids: Direct Allylic Amination Reaction of Isopimaric Acid Derivatives.  |  Timoshenko, MA., et al. 2016. ChemistryOpen. 5: 65-70. PMID: 27308214
  2. Rapid Stability Indicating HPLC Method for the Analysis of Leflunomide and Its Related Impurities in Bulk Drug and Formulations.  |  Mallu, UR., et al. 2019. Turk J Pharm Sci. 16: 457-465. PMID: 32454750
  3. Coupling of Alternating Current to Transition-Metal Catalysis: Examples of Nickel-Catalyzed Cross-Coupling.  |  Bortnikov, EO. and Semenov, SN. 2021. J Org Chem. 86: 782-793. PMID: 33186048
  4. Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP).  |  Brittain, WDG. and Cobb, SL. 2021. Org Lett. 23: 5793-5798. PMID: 34251217
  5. Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels.  |  El-Sayed, NS., et al. 2022. J Med Chem. 65: 303-322. PMID: 34962403
  6. Trifluoroethanol Promoted Castagnoli-Cushman Cycloadditions of Imines with Homophthalic Anhydride.  |  Bayles, T. and Guillou, C. 2022. Molecules. 27: PMID: 35164109
  7. A Chemo- and Regioselective Tandem [3 + 2]Heteroannulation Strategy for Carbazole Synthesis: Combining Two Mechanistically Distinct Bond-Forming Processes.  |  Campbell, E., et al. 2022. J Org Chem. 87: 4603-4616. PMID: 35302774
  8. Platinum-copper alloy nanoparticles armored with chloride ion transporter to promote electro-driven tumor inhibition.  |  Chen, T., et al. 2022. Bioact Mater. 12: 143-152. PMID: 35310378
  9. Enantioselective Cobalt-Catalyzed Hydroboration of Fluoroalkyl-Substituted Alkenes to Access Chiral Fluoroalkylboronates.  |  Hu, M., et al. 2022. J Am Chem Soc. 144: 15333-15338. PMID: 35953077
  10. Discovery of Novel Cinnamide Fungicidal Leads with Optical Hydroxyl Side Chain.  |  Wang, W., et al. 2022. Molecules. 27: PMID: 36014496
  11. Study of Biological Activities and ADMET-Related Properties of Salicylanilide-Based Peptidomimetics.  |  Pindjakova, D., et al. 2022. Int J Mol Sci. 23: PMID: 36232947
  12. Enantioselective Ugi and Ugi-azide reactions catalyzed by anionic stereogenic-at-cobalt(III) complexes.  |  Sun, BB., et al. 2022. Nat Commun. 13: 7065. PMID: 36400776
  13. The Use of Aryl-Substituted Homophthalic Anhydrides in the Castagnoli-Cushman Reaction Provides Access to Novel Tetrahydroisoquinolone Carboxylic Acid Bearing an All-Carbon Quaternary Stereogenic Center.  |  Moshnenko, N., et al. 2022. Molecules. 27: PMID: 36500582

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-(Trifluoromethyl)aniline, 100 g

sc-209872
100 g
$41.00