Date published: 2025-12-16

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4-(Trifluoromethyl)anisole (CAS 402-52-8)

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Alternate Names:
1-Methoxy-4-(trifluoromethyl)benzene; 4-Methoxybenzotrifluoride; Methyl 4-(trifluoromethyl)phenyl ether
Application:
4-(Trifluoromethyl)anisole is a fluorinated compound used for biochemical research
CAS Number:
402-52-8
Molecular Weight:
176.14
Molecular Formula:
C8H7F3O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-(Trifluoromethyl)anisole is a fluorinated compound used for biochemical research. 4-(Trifluoromethyl)anisole (TFMA) is an organic compound. This colorless liquid exhibits solubility in various organic solvents and emits a pungent odor. It serves as a valuable reagent in organic synthesis and plays a role as an intermediate in the production of agrochemicals. TFMA goes by several names, including trifluoromethyl anisole, trifluoromethylanisole, and trifluoromethyl phenyl ether. In the realm of scientific research, TFMA has found versatile applications. It has been utilized for synthesizing novel organic compounds, such as trifluoromethylated indoles and trifluoromethylated phenols. Moreover, TFMA has proven itself as a catalyst in polymer synthesis and polyurethane production, leading to the creation of polymers with enhanced physical properties. Though the precise mechanism of action for TFMA remains partially elusive, it is thought to function as a catalyst in polymer and polyurethane synthesis. Additionally, it is believed to act as a reagent in the synthesis of organic compounds like trifluoromethylated indoles and trifluoromethylated phenols, further enhancing its significance in the scientific community.


4-(Trifluoromethyl)anisole (CAS 402-52-8) References

  1. Laboratory Evaluation of Natural and Synthetic Aromatic Compounds as Potential Attractants for Male Mediterranean fruit Fly, Ceratitis capitata.  |  Tabanca, N., et al. 2019. Molecules. 24: PMID: 31261896
  2. Sandmeyer trifluoromethylthiolation of arenediazonium salts with sodium thiocyanate and Ruppert–Prakash reagent  |  Grégory Danoun, Bilguun Bayarmagnai, Matthias F. Gruenberg and Lukas J. Goossen *. 2014. Chem. Sci. 5: 1312-1316.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-(Trifluoromethyl)anisole, 1 g

sc-356871
1 g
$44.00

4-(Trifluoromethyl)anisole, 5 g

sc-356871A
5 g
$184.00