4-Thiothymidine (CAS 7236-57-9)

4-Thiothymidine (4-ThioT) is a nucleoside analog widely utilized in scientific research due to its significance and versatility. This thymidine analog has been extensively employed in biochemical and physiological experiments to investigate gene expression and protein synthesis. Furthermore, it has found applications in studying the effects of various drugs, toxins, DNA damage, and repair on cellular systems. It is utilized in DNA sequencing and gene expression studies to examine the impacts of different drugs and toxins on cellular processes. Moreover, it has been instrumental in studying DNA damage and repair mechanisms. Additionally, researchers have utilized 4-Thiothymidine to investigate the effects of mutations on protein synthesis and explore drug-resistant bacterial strains. Being a thymidine analog, 4-Thiothymidine becomes incorporated into DNA and RNA during replication. It can also be incorporated into proteins, leading to interference with their normal function. Moreover, 4-Thiothymidine has the ability to interact with DNA repair enzymes, inhibiting their activity. Consequently, this interference can result in the accumulation of mutations and the emergence of drug resistance in cells.