Date published: 2026-1-7

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4-tert-Octylphenol (CAS 140-66-9)

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Alternate Names:
4-(1,1,3,3-Tetramethylbutyl)phenol
Application:
4-tert-Octylphenol is common environmental pollutant
CAS Number:
140-66-9
Purity:
>93%
Molecular Weight:
206.32
Molecular Formula:
C14H22O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-tert-Octylphenol as a surfactant and emulsifier in experimental applications, it interacts with hydrophobic and hydrophilic molecules, facilitating the dispersion of non-polar substances in aqueous solutions. At the molecular level, 4-tert-Octylphenol disrupts the lipid bilayer of cell membranes, altering their permeability and affecting cellular processes. 4-Tert-Octylphenol also exhibits endocrine-disrupting properties by binding to hormone receptors and interfering with hormonal signaling pathways. 4-tert-Octylphenol can act as a precursor in the synthesis of other organic compounds, contributing to the development of new materials and substances. Its mechanism of action involves influencing the behavior of biological systems and serving as a building block for the creation of novel chemical entities.


4-tert-Octylphenol (CAS 140-66-9) References

  1. Effects of Bisphenol A and 4-tert-Octylphenol on Embryo Implantation Failure in Mouse.  |  Tran, DN., et al. 2018. Int J Environ Res Public Health. 15: PMID: 30061528
  2. Environmental Water Pollution, Endocrine Interference and Ecotoxicity of 4-tert-Octylphenol: A Review.  |  Olaniyan, LWB., et al. 2020. Rev Environ Contam Toxicol. 248: 81-109. PMID: 30460491
  3. Metabolomics Reveals Metabolic Changes Caused by Low-Dose 4-Tert-Octylphenol in Mice Liver.  |  Zhou, K., et al. 2018. Int J Environ Res Public Health. 15: PMID: 30487447
  4. Biodegradation and toxicity reduction of nonylphenol, 4-tert-octylphenol and 2,4-dichlorophenol by the ascomycetous fungus Thielavia sp HJ22: Identification of fungal metabolites and proposal of a putative pathway.  |  Mtibaà, R., et al. 2020. Sci Total Environ. 708: 135129. PMID: 31806325
  5. 4-Nonylphenol and 4-tert-octylphenol induce anxiety-related behaviors through alternation of 5-HT receptors and transporters in the prefrontal cortex.  |  Yang, J., et al. 2020. Comp Biochem Physiol C Toxicol Pharmacol. 230: 108701. PMID: 31911191
  6. Molecular interactions of thyroxine binding globulin and thyroid hormone receptor with estrogenic compounds 4-nonylphenol, 4-tert-octylphenol and bisphenol A metabolite (MBP).  |  Sheikh, IA. 2020. Life Sci. 253: 117738. PMID: 32360618
  7. Transcriptomic profiles of the ovaries from piglets neonatally exposed to 4-tert-octylphenol.  |  Knapczyk-Stwora, K., et al. 2020. Theriogenology. 153: 102-111. PMID: 32450468
  8. 17α-ethinylestradiol and 4-tert-octylphenol concurrently disrupt the immune response of common carp.  |  Maciuszek, M., et al. 2020. Fish Shellfish Immunol. 107: 238-250. PMID: 33038508
  9. Distribution and mass loads of xenoestrogens bisphenol a, 4-nonylphenol, and 4-tert-octylphenol in rainfall runoff from highly urbanized regions: A comparison with point sources of wastewater.  |  Zhao, JL., et al. 2021. J Hazard Mater. 401: 123747. PMID: 33113730
  10. 4-tert-Octylphenol Exposure Disrupts Brain Development and Subsequent Motor, Cognition, Social, and Behavioral Functions.  |  Tran, DN., et al. 2020. Oxid Med Cell Longev. 2020: 8875604. PMID: 33294128
  11. Simultaneous Quantification of Bisphenol-A and 4-Tert-Octylphenol in the Live Aquaculture Feed Artemia franciscana and in Its Culture Medium Using HPLC-DAD.  |  Giamaki, D., et al. 2022. Methods Protoc. 5: PMID: 35645346
  12. Competitive removal mechanism to simultaneously incarcerate bisphenol A, triclosan and 4-tert-octylphenol within beta-cyclodextrin crosslinked citric acid used for encapsulation in polypropylene membrane protected-micro-solid-phase extraction.  |  Hafiz Rozaini, MN., et al. 2022. Chemosphere. 309: 136626. PMID: 36181856
  13. Efficient elimination of nonylphenol and 4-tert-octylphenol by weak electrical stimulated anaerobic microbial processes.  |  Wang, C., et al. 2023. Chemosphere. 320: 138085. PMID: 36758818

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-tert-Octylphenol, 25 g

sc-210155
25 g
$45.00