4-(tert-Butyldimethylsilyl)oxy-1-butanol (CAS 87184-99-4)
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4-(tert-Butyldimethylsilyl)oxy-1-butanol is a compound that functions as a protecting group in organic synthesis. It is used to protect hydroxyl groups in various organic reactions, preventing unwanted side reactions and allowing for selective manipulation of specific functional groups. 4-(Tert-Butyldimethylsilyl)Oxy-1-Butanol acts by forming a stable silyl ether, which can be easily removed under mild conditions, making it versatile in the synthesis of complex organic molecules. Its mechanism of action involves the formation of a covalent bond between the hydroxyl group and the silicon atom, effectively masking the reactivity of the hydroxyl group. This allows for the manipulation of other functional groups within the molecule without affecting the protected hydroxyl group.
4-(tert-Butyldimethylsilyl)oxy-1-butanol (CAS 87184-99-4) References
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- Total syntheses of multiple cladiellin natural products by use of a completely general strategy. | Clark, JS., et al. 2013. J Org Chem. 78: 673-96. PMID: 23215006
- Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells. | Seifert, T., et al. 2014. J Med Chem. 57: 9870-88. PMID: 25383691
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-(tert-Butyldimethylsilyl)oxy-1-butanol, 5 g | sc-254578 | 5 g | $51.00 |