4-Pyridinecarbonitrile (CAS 100-48-1)
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4-Pyridinecarbonitrile is a reagent for the synthesis of 1-tolyl-5-benzylthiotetrazole and 2-hexylthio-4-pyridinecarbonitrile, which are antituberculotics. 4-Pyridinecarbonitrile plays a role in the preparation of Pinacidil, an antihypertensive agent, through chemoselective and environmentally friendly oxidative rearrangement reactions. It has also been utilized in the discovery of inhibitors for human L-xylulose reductase (XR), an enzyme involved in glucose metabolism. The compound is a white solid, soluble in water and polar solvents. Upon exposure to hydrochloric acid, 4-Pyridinecarbonitrile undergoes a reaction leading to the formation of picolinic acid. Additionally, x-ray crystallography has been used to determine the crystal structures of 4-Pyridinecarbonitrile and its quinoline derivatives when bound to specific molecules.
4-Pyridinecarbonitrile (CAS 100-48-1) References
- Photochemical substitution reactions of 4‐Pyridinecarbonitrile with aliphatic alcohols in neutral and acidified medium | Tullio Carolina, Angelo Clerici, Dianella Coggiola, Sergio Morrocchi. 1981. 18: 1421-1423.
- Photochemical induced formation of α‐alkylamino or alkylaminyl radicals from secondary amines: Reaction with 4‐pyridinecarbonitrile | Tullio Caronna, Sergio Morrocchi. 1992. 29: 975-977.
- A novel aminoalkyl-decyanation of 4-pyridinecarbonitrile with imines: A facile selective synthesis of 4-pyridinemethanamines | Xianmou Zeng ∗, Xiwen Chen, Jiaqiang Cai, Xiaoyun Jiang, Yijian Gu. 1996. Tetrahedron Letters. 37: 3009-3010.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Pyridinecarbonitrile, 25 g | sc-223665A | 25 g | $13.00 | |||
4-Pyridinecarbonitrile, 100 g | sc-223665 | 100 g | $20.00 | |||
4-Pyridinecarbonitrile, 500 g | sc-223665B | 500 g | $82.00 | |||
4-Pyridinecarbonitrile, 2.5 kg | sc-223665C | 2.5 kg | $198.00 |