4-(Pyridin-2-yl-aminocarbonyl)benzeneboronic acid (CAS 850568-25-1)

GABA T-3 inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of the GABA transporter type 3 (GABA T-3), a protein encoded by the SLC6A11 gene. The SLC6A11 gene belongs to the solute carrier family 6, which is involved in the transport of neurotransmitters across cell membranes. GABA T-3 is particularly responsible for the reuptake of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. By transporting GABA from the synaptic cleft back into presynaptic neurons, GABA T-3 plays a crucial role in regulating GABAergic signaling and maintaining the balance between excitation and inhibition in neural circuits. Structurally, GABA T-3 inhibitors can encompass a diverse array of molecules, including small molecules, peptides, or larger biomolecules that are engineered to interact specifically with the transporter′s active site or other critical regions. These inhibitors typically function by blocking the GABA binding site or altering the conformation of the GABA T-3 protein, thereby preventing the reuptake of GABA into neurons. By inhibiting GABA T-3, these compounds can increase the concentration of GABA in the synaptic cleft, thereby enhancing inhibitory neurotransmission. The study of GABA T-3 inhibitors is crucial for understanding the mechanisms of neurotransmitter transport and the broader implications of GABAergic signaling on neural function. Research into these inhibitors provides valuable insights into the regulation of synaptic transmission, highlighting the importance of neurotransmitter transporters in maintaining the homeostasis of neural circuits. By exploring the effects of GABA T-3 inhibition, scientists can gain a deeper understanding of the physiological and biochemical pathways influenced by GABA transporters, revealing the significance of these proteins in modulating neuronal activity and overall brain function.